Phosducin

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PDC
Protein PDC PDB 2trc.png
Identifiers
Aliases PDC, MEKA, PHD, PhLOP, PhLP, phosducin
External IDs MGI: 98090 HomoloGene: 1950 GeneCards: 5132
RNA expression pattern
PBB GE PDC 211496 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002597
NM_022576
NM_022577

NM_001159730
NM_024458

RefSeq (protein)

NP_002588.3
NP_072098.1
NP_002588.3

NP_001153202.1
NP_077778.1

Location (UCSC) Chr 1: 186.44 – 186.46 Mb Chr 1: 150.32 – 150.33 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Phosducin, also known as PDC, is a human protein and gene.[1] It belongs to phosducin family of proteins.

This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. By associating with these subunits only, the Transducin alpha subunit will remain active for longer. This will increase the amount of time of visual excitation.

This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]

See also[edit]

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Further reading[edit]