(E/Z)-[3-Chloro-4-(diethylamino)-4-oxobut-2-en-2-yl] dimethyl phosphate
3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||299.69 g·mol−1|
|Melting point||120 to 123 °C (248 to 253 °F; 393 to 396 K)|
|Boiling point||162 °C (324 °F; 435 K) (1.5 mmHg)|
|Lethal dose or concentration (LD, LC):|
LD50 (median dose)
|13 mg/kg (mouse, oral)|
6 mg/kg (mouse, IV)
20 mg/kg (rat, oral)
26 mg/kg (rat, subcut.)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Toxicity and regulation
Phosphamidon is very highly toxic to mammals and is listed as WHO Hazard Class Ia. A harvester developed symptoms of moderately severe poisoning after working in a field that had been sprayed with the chemical 2 weeks earlier. He collapsed and exhibited significant depression of serum cholinesterase, but recovered completely within 2 days after successful treatment with atropine. International trade of phosphamidon is covered by the Rotterdam Convention.
- Data Sheet on Pesticides No. 74: Phosphamidon, International Programme on Chemical Safety
- Bachmann, Fritz (1960). "Phosphamidon, a new phosphate ester with systemic action". Proc. Intern. Cong. Crop. Protection, 4th Congr., Hamburg. 2: P1153–1155.
- Jacques, R.; Bein, H. J. (1960). "Toxicology and pharmacology of a new systemic phosphoric acid ester insecticide phosphamidon (2-chloro-2-diethylcarbamoyl-1-methylvinyl dimethyl phosphate)". Archiv für Toxikologie. 18: 316–330. doi:10.1007/BF02226232.
- S. Gitelson, J. T. Davidson, A. Werczberger. Phosphamidon poisoning. Br. J. Ind. Med. 22: 236-239, 1965.