Phosphatidic acid phosphatase 2c

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PLPP2
Identifiers
Aliases PLPP2, LPP2, PAP-2c, PAP2-g, PPAP2C, Phosphatidic acid phosphatase 2c, phospholipid phosphatase 2
External IDs MGI: 1354945 HomoloGene: 2752 GeneCards: PLPP2
RNA expression pattern
PBB GE PPAP2C 209529 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003712
NM_177526
NM_177543

NM_015817
NM_001302389
NM_001302390
NM_001302442

RefSeq (protein)

NP_003703
NP_803545
NP_808211

Location (UCSC) Chr 19: 0.28 – 0.29 Mb Chr 10: 79.53 – 79.53 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Lipid phosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the PPAP2C gene.[3][4][5]

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Leung DW, Tompkins CK, White T (May 1998). "Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells". DNA Cell Biol. 17 (4): 377–85. doi:10.1089/dna.1998.17.377. PMID 9570154. 
  4. ^ Hooks SB, Ragan SP, Lynch KR (Jun 1998). "Identification of a novel human phosphatidic acid phosphatase type 2 isoform". FEBS Lett. 427 (2): 188–92. doi:10.1016/S0014-5793(98)00421-9. PMID 9607309. 
  5. ^ a b "Entrez Gene: PPAP2C phosphatidic acid phosphatase type 2C". 

Further reading[edit]