sn-1-stearoyl-2-arachidonoyl phosphatidylinositol 3-phosphate
|Molar mass||470.214 g/mol, neutral with fatty acid composition - 18:0, 20:4|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is: / ?)(|
Phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) is a phospholipid found in cell membranes that helps to recruit a range of proteins, many of which are involved in protein trafficking, to the membranes. It is the product of both the class II and III phosphoinositide 3-kinases (PI 3-kinases) activity on phosphatidylinositol.
The majority of PtdIns3P appears to be constitutively synthesised by the class III PI 3-kinase, Vps34, at endocytic membranes. Class II PI 3-kinases also appear to synthesise PtdIns3P, their activity however appears to be regulated by a range of stimuli, including growth factors. This suggests that specific pools of PtdIns3P may be synthesised upon cell stimulation.
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