Phosphatidylinositol diacylglycerol-lyase

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
phosphatidylinositol diacylglycerol-lyase
Identifiers
EC number4.6.1.13
CAS number37288-19-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Phosphatidylinositol-specific phospholipase C, image from OPM database

In enzymology, a phosphatidylinositol diacylglycerol-lyase (EC 4.6.1.13) is an enzyme that catalyzes the chemical reaction

1-phosphatidyl-1D-myo-inositol 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol

Hence, this enzyme has one substrate, 1-phosphatidyl-1D-myo-inositol, and two products, 1D-myo-inositol 1,2-cyclic phosphate and 1,2-diacyl-sn-glycerol.

This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming). Other names in common use include monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, 1-phosphatidylinositol phosphodiesterase, 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase, (cyclic-phosphate-forming), 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase, and (1,2-cyclic-phosphate-forming). This enzyme participates in inositol phosphate metabolism.

Structural studies[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T6M and 2OR2.

References[edit]

  • Allan D, Michell RH (1974). "Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes. Activity at pH5.5 and pH7.0". Biochem. J. 142 (3): 591&ndash, 7. PMC 1168323. PMID 4377210.
  • Friedel RO, Brown JD, Durell (1967). "Monophosphatidyl inositol inositolphosphohydrolase in guinea-pig brain". Biochim. Biophys. Acta. 144 (3): 684&ndash, 6. doi:10.1016/0005-2760(67)90059-8. PMID 4294905.
  • Irvine RF (1982). "The enzymology of stimulated inositol lipid turnover". Cell. Calcium. 3 (4–5): 295&ndash, 309. doi:10.1016/0143-4160(82)90018-5. PMID 6297738.
  • Michell RH, Allan D (1975). "Inositol cyclis phosphate as a product of phosphatidylinositol breakdown by phospholipase C (Bacillus cereus)". FEBS Lett. 53 (3): 302&ndash, 4. doi:10.1016/0014-5793(75)80041-X. PMID 236918.
  • Low MG, Finean JB (1977). "Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C". Biochem. J. 167 (1): 281&ndash, 4. PMC 1183647. PMID 588258.
  • Henner DJ, Yang M, Chen E, Hellmiss R, Rodriguez H, Low MG (1988). "Sequence of the Bacillus thuringiensis phosphatidylinositol specific phospholipase C". Nucleic Acids Res. 16 (21): 10383. doi:10.1093/nar/16.21.10383. PMC 338883. PMID 3194218.