Phosphatidylmyo-inositol mannosides

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Phosphatidylmyo-inositol Mannosides (PIMs) are a family of glycolipids found in the cell wall of Mycobacterium tuberculosis. PIMs influence the interaction of the immune system with M. tuberculosis, and mice that develop antibodies for this family of glycolipids are better at sustaining or defeating a M. tuberculosis infection.[1][2] Thus, PIMs are important glycolipids associated with M. tuberculosis, but are also likely involved with the process by which M. tuberculosis subverts the immune system.[3][4][5][6][7]


  1. ^ Mehta, P. K., and G. K. Khuller. 1988. Protective immunity to experimental tuberculosis by mannophosphoinositides of mycobacteria. Med. Microbiol. Immunol. (Berlin) 177:265–284.
  2. ^ Singh, A. P., and G. K. Khuller. 1993. Liposomes as a carrier for mannophosphoinositide antigens of mycobacteria. Indian J. Biochem. Biophys. 30:160–165.
  3. ^ Fratti, R. A., J. M. Backer, J. Gruenberg, S. Corvera, and V. Deretic. 2001. Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest. J. Cell Biol. 154:631–644.
  4. ^ Kaplan, G., R. R. Gandhi, D. E. Weinstein, W. R. Levis, M. E. Patarroyo, P. J. Brennan, and Z. A. Cohn. 1987. Mycobacterium leprae antigen-induced suppression of T cell proliferation in vitro. J. Immunol. 138:3028–3034.
  5. ^ Sibley, L. D., L. B. Adams, and J. L. Krahenbuhl. 1990. Inhibition of interferon-gamma-mediated activation in mouse macrophages treated with lipoarabinomannan. Clin. Exp. Immunol. 80:141–148.
  6. ^ Vergne, I., J. Chua, and V. Deretic. 2003. Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2!/calmodulin-PI3K hVPS34 cascade. J. Exp. Med. 198:653–659.
  7. ^ Vergne, I., R. A. Fratti, P. J. Hill, J. Chua, J. Belisle, and V. Deretic. 2004. Mycobacterium tuberculosis phagosome maturation arrest: mycobacterial phosphatidylinositol analog phosphatidylinositol mannoside stimulates early endosomal fusion. Mol. Biol. Cell 15:751–760.