Phosphoadenylylsulfatase

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phosphoadenylylsulfatase
Identifiers
EC number3.6.2.2
CAS number37289-37-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a phosphoadenylylsulfatase (EC 3.6.2.2) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + H2O adenosine 3',5'-bisphosphate + sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and H2O, whereas its two products are adenosine 3',5'-bisphosphate and sulfate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in sulfonyl-containing anhydrides. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate sulfohydrolase. Other names in common use include 3-phosphoadenylyl sulfatase, 3-phosphoadenosine 5-phosphosulfate sulfatase, PAPS sulfatase, and 3'-phosphoadenylylsulfate sulfohydrolase. This enzyme participates in sulfur metabolism. It employs one cofactor, manganese.

References[edit]

  • BALASUBRAMANIAN AS, BACHHAWAT BK (1962). "Enzymic degradation of active sulphate". Biochim. Biophys. Acta. 59 (2): 389–97. doi:10.1016/0006-3002(62)90188-9. PMID 13864264.