Phosphogluconate dehydratase

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phosphogluconate dehydratase
EC number4.2.1.12
CAS number9024-33-3
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
2-keto-3-deoxy-6-phosphogluconate, a product of the reaction catalysed by phosphogluconate dehydratase

In enzymology, a phosphogluconate dehydratase (EC is an enzyme that catalyzes the chemical reaction

6-phospho-D-gluconate 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O

Hence, this enzyme has one substrate, 6-phospho-D-gluconate, and two products, 2-dehydro-3-deoxy-6-phospho-D-gluconate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming). Other names in common use include 6-phosphogluconate dehydratase, 6-phosphogluconic dehydrase, gluconate-6-phosphate dehydratase, gluconate 6-phosphate dehydratase, 6-phosphogluconate dehydrase, and 6-phospho-D-gluconate hydro-lyase. This enzyme participates in Entner–Doudoroff pathway.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GP4.


  • MELOCHE HP, WOOD WA (1964). "The Mechanism of 6-Phosphogluconic Dehydrase". J. Biol. Chem. 239: 3505–10. PMID 14245409.