Phosphomevalonate kinase

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PMVK
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPMVK, HUMPMKI, PMK, PMKA, PMKASE, POROK1, phosphomevalonate kinase
External IDsOMIM: 607622 MGI: 1915853 HomoloGene: 4779 GeneCards: PMVK
EC number2.7.4.2
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PMVK
Genomic location for PMVK
Band1q21.3Start154,924,740 bp[1]
End154,936,719 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006556
NM_001323011
NM_001323012
NM_001348696

NM_026784
NM_027348
NM_001310640

RefSeq (protein)

NP_001309940
NP_001309941
NP_006547
NP_001335625

NP_001297569
NP_081060
NP_081624

Location (UCSC)Chr 1: 154.92 – 154.94 MbChr 3: 89.45 – 89.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Phosphomevalonate kinase
Identifiers
EC number2.7.4.2
CAS number9026-46-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Phosphomevalonate kinase
Identifiers
SymbolPMVK
NCBI gene10654
HGNC9141
OMIM607622
RefSeqNM_006556
UniProtQ15126
Other data
EC number2.7.4.2
LocusChr. 1 p13-q23

Phosphomevalonate kinase is an enzyme (EC 2.7.4.2) in the mevalonate pathway[5][6][7] that in humans is encoded by the PMVK gene.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163344 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027952 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bloch K, Chaykin S, Phillips AH, De Waard A (October 1959). "Mevalonic acid pyrophosphate and isopentenylpyrophosphate". The Journal of Biological Chemistry. 234: 2595–604. PMID 13801508.
  6. ^ Henning U, Moslein EM, Lynen F (July 1959). "Biosynthesis of terpenes. V. Formation of 5-pyrophosphomevalonic acid by phosphomevalonic kinase". Archives of Biochemistry and Biophysics. 83 (1): 259–67. doi:10.1016/0003-9861(59)90031-1. PMID 13662013.
  7. ^ Levy HR, Popjak G (June 1960). "Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver". The Biochemical Journal. 75: 417–28. doi:10.1042/bj0750417. PMC 1204488. PMID 14416398.

External links[edit]