Phosphopantothenoylcysteine decarboxylase

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phosphopantothenoylcysteine decarboxylase
EC no.
CAS no.9024-69-5
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a phosphopantothenoylcysteine decarboxylase (EC is an enzyme that catalyzes the chemical reaction

N-[(R)-4'-phosphopantothenoyl]-L-cysteine pantotheine 4'-phosphate + CO2

Hence, this enzyme has one substrate, [[N-[(R)-4'-phosphopantothenoyl]-L-cysteine]], and two products, pantotheine 4'-phosphate and CO2.

This enzyme belongs to the family of lyases, to be specific the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming). Other names in common use include 4-phosphopantotheoylcysteine decarboxylase, 4-phosphopantothenoyl-L-cysteine decarboxylase, PPC-decarboxylase, and N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase. This enzyme participates in coenzyme A (CoA) biosynthesis from pantothenic acid.

Structural studies[edit]

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1MVL, 1MVN, and 1QZU.


  • Brown GM (1958). "Requirement of cytidine triphosphate for the biosynthesis of phosphopantetheine". J. Am. Chem. Soc. 80 (12): 3161. doi:10.1021/ja01545a062.
  • Brown GM (February 1959). "The metabolism of pantothenic acid". The Journal of Biological Chemistry. 234 (2): 370–8. PMID 13630913.