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The insecticide fosthietan is a phosphoramidate

Phosphoramidates (sometimes also called amidophosphates) are a class of phosphorus compounds structurally related to phosphates (or organophosphates) via the substitution of an OR for a NR2. The structure of phosphoramidic acid (phosphoramidate), (HO)2PONH2, is present in PubChem.[1]
A phosphorodiamidate is a phosphate that has two of its OH groups substituted by NR2 groups to give a species with the general formula HOPO(NH)2.


Two examples of natural phosphoramidates are phosphocreatine and the phosphoramidate formed when histidine residues in histidine kinases are phosphorylated.[2] An example of a phosphorodiamidate is Morpholino which is used in molecular biology.

See also[edit]


  1. ^ "phosphoramidic acid - PubChem". 2013-09-25. Retrieved 2014-01-14. 
  2. ^ "Two-Component Signal Transduction". Annual Review of Biochemistry. 2000-07-01. Retrieved 2015-06-07.