phosphoribosyl-AMP cyclohydrolase dimer, Methanobacterium
|PDB structures||RCSB PDB PDBe PDBsum|
|Gene Ontology||AmiGO / QuickGO|
- 1-(5-phosphoribosyl)-AMP + H2O 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4-carboxamide
Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-AMP and H2O, whereas its two products are [[1-(5-phosphoribosyl)-5-[(5-]] and [[phosphoribosylamino)methylideneamino]imidazole-4-carboxamide]].
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase. Other names in common use include PRAMP-cyclohydrolase, and phosphoribosyladenosine monophosphate cyclohydrolase. This enzyme participates in histidine metabolism.
- Minson AC, Creaser EH (1969). "Purification of a trifunctional enzyme, catalysing three steps of the histidine pathway, from Neurospora crassa". Biochem. J. 114 (1): 49–56. doi:10.1042/bj1140049. PMC 1184794. PMID 4309307.
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