Phosphoribosyl-ATP diphosphatase

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
phosphoribosyl-ATP diphosphatase
1yxb.jpg
phosphoribosyl-ATP pyrophosphatase tetramer, Streptomyces coelicolor
Identifiers
EC number3.6.1.31
CAS number69553-55-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a phosphoribosyl-ATP diphosphatase (EC 3.6.1.31) is an enzyme that catalyzes the chemical reaction

1-(5-phosphoribosyl)-ATP + H2O 1-(5-phosphoribosyl)-AMP + diphosphate

Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-ATP and H2O, whereas its two products are 1-(5-phosphoribosyl)-AMP and diphosphate.

This enzyme participates in histidine metabolism. It employs one cofactor, H+.

Nomenclature[edit]

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is 1-(5-phosphoribosyl)-ATP diphosphohydrolase. Other names in common use include phosphoribosyl-ATP pyrophosphatase, and phosphoribosyladenosine triphosphate pyrophosphatase.

References[edit]

  • Smith DW, Ames BN (July 1965). "Phosphoribosyladenosine monophosphate, an intermediate in histidine biosynthesis". The Journal of Biological Chemistry. 240: 3056–63. PMID 14342333.