Phosphoribosyl pyrophosphate

From Wikipedia, the free encyclopedia
Jump to: navigation, search
"PRPP" redirects here. It is not to be confused with Pooled Retirement Pension Plan.
Phosphoribosyl pyrophosphate
Phosphoribosyl pyrophosphate.svg
Other names
5-phospho-alpha-D-ribose 1-diphosphate
7540-64-9 N
ChEBI CHEBI:17111 YesY
ChemSpider 7062 YesY
DrugBank DB01632 YesY
Jmol interactive 3D Image
MeSH Phosphoribosyl+pyrophosphate
PubChem 7339
Molar mass 390.07 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Phosphoribosyl pyrophosphate (PRPP) is a pentosephosphate.

It is formed from ribose 5-phosphate by the enzyme ribose-phosphate diphosphokinase.

It plays a role in transferring phospho-ribose groups in several reactions:

Enzyme Reactant Product
adenine phosphoribosyltransferase adenine AMP
hypoxanthine-guanine phosphoribosyltransferase guanine GMP
hypoxanthine-guanine phosphoribosyltransferase hypoxanthine IMP
orotate phosphoribosyltransferase orotate OMP
uracil phosphoribosyltransferase uracil UMP

In de novo generation of purines, the enzyme amidophosphoribosyltransferase acts upon PRPP to create phosphoribosylamine.

Increased PRPP[edit]

Increased levels of PRPP is characterized by the overproduction and accumulation of uric acid leading to hyperuricemia and hyperuricosuria. It is one of the causes of gout.

Increased levels of PRPP are present in Lesch-Nyhan Syndrome. Decreased levels of hypoxanthine guanine phosphoribosyl transferase (HGPRT) causes this accumulation, as PRPP is a substrate used by HGPRT during purine salvage.

See also[edit]