Phosphoribosylaminoimidazolesuccinocarboxamide

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Phosphoribosylaminoimidazolesuccinocarboxamide
Stereo structural formula of SAICAR
Names
Systematic IUPAC name
2-[(5-Amino-1-{3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl}-1H-imidazol-4-yl)formamido]butanedioic acid
Other names
SAICAR; 2-[(5-Amino-1-{3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl}imidazol-4-yl)formamido]butanedioic acid; N-{[5-Amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl}-L-aspartic acid
Identifiers
3031-95-6 YesY
3DMet B04963
ChEBI CHEBI:18319 N
ChemSpider 141175 YesY
Jmol-3D images Image
KEGG C04823 N
MeSH SAICAR
PubChem 160666
Properties
C13H19N4O12P
Molar mass 454.28 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) is an intermediate in the formation of purines. The conversion of ATP, L-aspartate, and 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide, ADP, and phosphate by phosphoribosylaminoimidazolesuccinocarboxamide synthetase (SAICAR synthetase) represents the eighth step of de novo purine nucleotide biosynthesis.[1]

References[edit]

  1. ^ Scott W. Nelson, Daniel J. Binkowski, Richard B. Honzatko, and Herbert J. Fromm (2005). "Mechanism of Action of Escherichia coli Phosphoribosylaminoimidazolesuccinocarboxamide Synthetase". Biochemistry 44 (2): 766–774. doi:10.1021/bi048191w. PMID 15641804.