Phosphoserine transaminase

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Phosphoserine transaminase
EC number
CAS number 9030-90-4
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Phosphoserine transaminase (EC, PSAT, phosphoserine aminotransferase, 3-phosphoserine aminotransferase, hydroxypyruvic phosphate-glutamic transaminase, L-phosphoserine aminotransferase, phosphohydroxypyruvate transaminase, phosphohydroxypyruvic-glutamic transaminase, 3-O-phospho-L-serine:2-oxoglutarate aminotransferase, SerC, PdxC, 3PHP transaminase) is an enzyme with systematic name O-phospho-L-serine:2-oxoglutarate aminotransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

(1) O-phospho-L-serine + 2-oxoglutarate 3-phosphonooxypyruvate + L-glutamate
(2) 4-phosphonooxy-L-threonine + 2-oxoglutarate (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate

This enzyme is a pyridoxal-phosphate protein.

See also[edit]


  1. ^ Hirsch, H.; Greenberg, D.M. (1967). "Studies on phosphoserine aminotransferase of sheep brain". J. Biol. Chem. 242 (9): 2283–2287. PMID 6022873. 
  2. ^ Pizer, L.I. (1963). "The pathway and control of serine biosynthesis in Escherichia coli". J. Biol. Chem. 238: 3934–3944. PMID 14086727. 
  3. ^ Zhao, G.; Winkler, M.E. (1996). "A novel α-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria". J. Bacteriol. 178 (1): 232–239. PMC 177644free to read. PMID 8550422. 
  4. ^ Drewke, C.; Klein, M.; Clade, D.; Arenz, A.; Müller, R.; Leistner, E. (1996). "4-O-phosphoryl-L-threonine, a substrate of the pdxC(serC) gene product involved in vitamin B6 biosynthesis". FEBS Lett. 390 (2): 179–182. doi:10.1016/0014-5793(96)00652-7. PMID 8706854. 
  5. ^ Zhao, G.; Winkler, M.E. (1996). "4-Phospho-hydroxy-L-threonine is an obligatory intermediate in pyridoxal 5′-phosphate coenzyme biosynthesis in Escherichia coli K-12". FEMS Microbiol. Lett. 135 (2-3): 275–280. doi:10.1111/j.1574-6968.1996.tb08001.x. PMID 8595869. 

External links[edit]