Phosphoserine phosphatase

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
phosphoserine phosphatase
EC no.
CAS no.9025-73-4
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a phosphoserine phosphatase (EC is an enzyme that catalyzes the following chemical reaction:

O-phospho-L(or D)-serine + H2O L(or D)-serine + phosphate ion

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is O-phosphoserine phosphohydrolase. This enzyme participates in glycine, serine and threonine metabolism.

Structural studies[edit]

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1F5S, 1J97, 1L7M, 1L7N, 1L7O, 1L7P, 1L8L, 1L8O, 1NNL, 2J6Y, 2J6Z, and 2J70.


  • BORKENHAGEN LF, KENNEDY EP (1959). "The enzymatic exchange of L-serine with O-phospho-L-serine catalyzed by a specific phosphatase". J. Biol. Chem. 234 (4): 849–53. PMID 13654276.
  • Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 5, Academic Press, New York, 1961, p. 73-78.
  • Neuhaus FC, Byrne WL (1959). "Metabolism of phosphoserine. II. Purification and properties of O-phosphoserine phosphatase". J. Biol. Chem. 234 (1): 113–121. PMID 13610904.