(Boemare et al. 1993) emend. Fischer-Le Saux et al. 1999
Photorhabdus is a genus of bioluminescent, gram-negative bacilli which lives symbiotically within entomopathogenic nematodes, hence the name photo (which means light-producing) and rhabdus (rod-shape)  . Photorhabdus is known to be pathogenic to a wide range of insects and has been used as biopesticide in agriculture.
Photorhabdus species facilitate the reproduction of entomopathogenic nematodes by infecting and killing susceptible insect larvae.  entomopathogenic nematodes are normally found in soil. Nematodes infect larval hosts by piercing the larval cuticle. When the nematode enters an insect larvae, Photorhabdus species are released by the nematodes and will produce a range of toxins, killing the host within 48 hours. Photorhabdus species feed on the cadaver of the insect and the process converts the cadaver into a nutrient source for the nematode. Mature nematodes leave the depleted body of the insect and search for new hosts to infect.
During stationary phase growth inside insect larvae, Photorhabdus species synthesize a molecule called 3,5-Dihydroxy-4-isopropyl-trans-stilbene (ST). It is proposed that 3,5-Dihydroxy-4-isopropyl-trans-stilbene (ST) acts as an antibiotic and protects Photorhabdus species from competition from other microorganisms, and also helps circumvent the insect's immune system. 
Photorhabdus species are essential endosymbionts for Heterorhabditis nematodes.
The complete genome of Photorhabdus luminescens was sequenced in 2003. The DNA sequence of Photorhabdus contains a number of toxin-encoding genes that are essential for killing the insect after infection. This includes genes encoding toxins that kill Manduca sexta, the tobacco hornworm, gene mcf that causes apoptosis in insect hemocytes and midgut epithelium, and genes that intervene in the development of insect host. 
It is proposed that Photorhabdus species acquired the toxin genes by horizontal gene transfer during evolution.
Photorhabdus in agriculture
The efficiency of insect-killing nature of Photorhabdus species and its potential use as biopesticide have been studied. Use of Photorhabdus species alone as biopesticide, independent of its nematode symbiont, against the cabbage white butterfly, Pieris brassicae, mango mealy bug, Drosicha mangiferae and the pupae of the diamond back moth, Plutella xylostella has been demonstrated successful. 
Photorhabdus as disease causing agent
Three species of Photohabdus have been found, which are Photorhabdus luminescens, Photorhabdus temperata and Photorhabdus asymbiotica. P.asymbiotica has been shown to be infectious to human, but the cases are mostly non-fatal and are restricted to Texas, USA and the Gold Coast of Australia. 
In 1999, a study reported another four cases of Photorhabdus luminescens infection in South Eastern Australia, one in 1994 and three in 1998. 
- David J.Clarke (2008). "Photorhabdus:shedding light on symbioses". microbiology today.
- Gerrard, John G (2003). "Photorhabdus Species: Bioluminescent Bacteria as Human Pathogens?". Emerging Infectious Diseases 9.
- Williamson, Valerie M., Kaya, Harry K (2003). "Sequence of a symbiont". Nature Biotechnology 21: 1924–1925. doi:10.1038/nbt1103-1294.
- Mohan Sharad,Sabir Naved (2005). "Biosafety concerns on the use of Photorhabdus luminescens as biopesticide : experimental evidence of mortality in egg parasitoid Trichogramma spp". Current Science 89: 1268–1272.
- Farmer JJ, Jorgensen JH, Grimont PAD, Ackhurst RJ, Poinar GO, Ageron E (1989). "Xenorhabdus luminescens (DNA hybridization group 5) from human clinical specimens". Journal of Clinical Microbiology 27: 1594–600.
- Peel,M.M et al. (1999). "Isolation, identification, and molecular characterization of strains of Photorhabdus luminescens from infected humans in Australia". Journal of Clinical Microbiology 37: 3647–3653.
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