Phthalide

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Phthalide
Phthalide.svg
Names
IUPAC name
2-Benzofuran-1(3H)-one
Other names
Phthalolactone
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.001.586
UNII
Properties
C8H6O2
Molar mass 134.134 g·mol−1
Melting point 75 to 77 °C (167 to 171 °F; 348 to 350 K)[1]
Boiling point 290 °C (554 °F; 563 K)[2]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Phthalide is an organic chemical compound with the molecular formula C8H6O2. It is a lactone that serves as the core chemical structure for a variety of more complex chemical compounds including dyes (such as phenolphthalein), fungicides (such as tetrachlorophthalide, often referred to simply as "phthalide"), and natural oils (such as butylphthalide).

Uses[edit]

Phthalide is used in the synthesis of several pharmaceutical drugs including isoxepac, vatalanib, and hydralazine as well as the pesticide kresoxim-methyl [de].[citation needed]

Examples[edit]

References[edit]

  1. ^ Kumar, R. Arun; Maheswari, C. Uma; Ghantasala, Satheesh; Jyothi, C.; Reddy, K. Rajender (2011). "Synthesis of 3H-Quinazolin-4-ones and 4H-3,1-Benzoxazin-4-ones via Benzylic Oxidation and Oxidative Dehydrogenation using Potassium Iodide-tert-Butyl Hydroperoxide". Advanced Synthesis & Catalysis. 353 (2+3): 401–410. doi:10.1002/adsc.201000580.
  2. ^ Kus, Nermin Simsek (2008). "Some oxidation reactions with molecular oxygen in subcritical water". Asian Journal of Chemistry. 20 (2): 1226–1230.