|Group:||Group I (dsDNA)|
Phycodnaviridae is a family of large (100-560kb) double stranded DNA viruses that infect marine or freshwater eukaryotic algae. There are currently 33 species in this family, divided among 6 genera. This family belongs to a super-group of large viruses known as nucleocytoplasmic large DNA viruses (NCLDVs).
The taxonomy of this family was initially based on the host range: chloroviruses infect chlorella-like green algae from terrestrial waters, whereas members of the other five genera infect marine green and brown algae. This was subsequently confirmed by analysis of their DNA polymerases.
Viruses in Phycodnaviridae are enveloped, with icosahedral and round geometries, and T=169 symmetry. The diameter is around 100-220 nm. They have an internal lipid membrane and replicate, completely or partly, in the cytoplasm of their host cells.
|Genus||Structure||Symmetry||Capsid||Genomic Arrangement||Genomic Segmentation|
Viral replication is nucleo-cytoplasmic, and is lysogenic. Replication follows the DNA strand displacement model. DNA-templated transcription is the method of transcription. The virus exits the host cell by lysis via lytic phospholipids. Alga serve as the natural host. Transmission routes are passive diffusion.
|Genus||Host Details||Tissue Tropism||Entry Details||Release Details||Replication Site||Assembly Site||Transmission|
|Raphidovirus||Alga||None||Cell receptor endocytosis||Lysis||Nucleus||Cytoplasm||Passive diffusion|
|Coccolithovirus||Alga||None||Cell receptor endocytosis||Budding||Nucleus||Cytoplasm||Passive diffusion|
|Phaeovirus||Alga||None||Cell receptor endocytosis||Lysis||Nucleus||Cytoplasm||Passive diffusion|
|Chlorovirus||Alga||None||Cell receptor endocytosis||Lysis||Nucleus||Cytoplasm||Unknown|
|Prymnesiovirus||Alga||None||Cell receptor endocytosis||Lysis||Nucleus||Cytoplasm||Passive diffusion|
|Prasinovirus||Alga||None||Cell receptor endocytosis||Lysis||Nucleus||Cytoplasm||Passive diffusion|
Recent studies have revealed features in Phycodnavirus genomes such as sophisticated replication and transcription machineries, a novel type of potassium channel protein, genes involved in inducing apoptosis in the host genome, a sophisticated signal transduction and gene regulation system and genes for glycosylation of viral proteins.
All phycodnaviruses encode a number of proteins involved in DNA replication or recombination, including a DNA-directed DNA polymerase. It is unclear if any phycodnaviruses encode a fully functional replication machinery, however. They are thought to rely on host enzymes at least partially.
Until recently phycodnaviruses were believed to infect algal species exclusively. Recently, DNA homologous to Chlorovirus Acanthocystis turfacea virus 1 (ATCV-1) were isolated from human nasopharyngeal mucosal surfaces. The presence of ATCV-1 in the human microbiome was associated with diminished performance on cognitive assessments. Inoculation of ATCV-1 in experimental animals was associated with decreased performance in memory and sensory-motor gating, as well as altered expression of genes in the hippocampus related to synaptic plasticity, learning, memory formation, and the viral immune response.
Phycodnaviruses are a diverse collection of viruses with similar particles, which, despite the fact they have ~1000 genes, share only 13 of them between viruses in different genera.
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- World of Chlorella Viruses Home Page