Vitamin K1; phytomenadione; phytonadione
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|Molar mass||450.70 g/mol|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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It is a fat-soluble vitamin that is stable to air and moisture but decomposes in sunlight. It is found naturally in a wide variety of green plants, particularly leaves, since it functions as an electron acceptor during photosynthesis, forming part of the electron transport chain of Photosystem I.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
A stereoisomer of phylloquinone is called vitamin k1 (note the difference in capitalization).
Its best-known function in animals is as a cofactor in the formation of coagulation factors II (prothrombin), VII, IX, and X by the liver. It is also required for the formation of anticoagulant factors protein C and S. It is commonly used to treat warfarin toxicity, and as an antidote for coumatetralyl.
Vitamin K is required for bone protein formation.
- "WHO Model List of Essential Medicines: 18th list" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
- Haroon Y, Shearer MJ, Rahim S, Gunn WG, McEnery G, Barkhan P (June 1982). "The content of phylloquinone (vitamin K1) in human milk, cows' milk, and infant formula foods determined by high-performance liquid chromatography". J. Nutr. 112 (6): 1105–17. PMID 7086539.
- "Vitamin K". Retrieved 2009-03-18.
- "Vitamin K: Phylloquinone". TrackMyStack. Retrieved 23 August 2015.