Phylloquinone monooxygenase (2,3-epoxidizing)

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phylloquinone monooxygenase (2,3-epoxidizing)
EC no.
CAS no.54596-37-1
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a phylloquinone monooxygenase (2,3-epoxidizing) (EC is an enzyme that catalyzes the chemical reaction

phylloquinone + AH2 + O2 2,3-epoxyphylloquinone + A + H2O

The three substrates of this enzyme are phylloquinone, an electron acceptor AH2, and O2, whereas its three products are 2,3-epoxyphylloquinone, the reduction product A, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is phylloquinone,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing). Other names in common use include phylloquinone epoxidase, vitamin K 2,3-epoxidase, vitamin K epoxidase, and vitamin K1 epoxidase.


  • Willingham AK, Matschiner JT (1974). "Changes in phylloquinone epoxidase activity related to prothrombin synthesis and microsomal clotting activity in the rat". Biochem. J. 140 (3): 435–41. PMC 1168020. PMID 4155625.