Picotamide

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Picotamide
Picotamide.png
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Identifiers
PubChem CID
ChemSpider
UNII
ECHA InfoCard 100.046.572
Chemical and physical data
Formula C21H20N4O3
Molar mass 376.409 g/mol
3D model (Jmol)
  (verify)

Picotamide is a platelet aggregation inhibitor. It works as a thromboxane synthase inhibitor and a thromboxane receptor inhibitor, the latter by modifying cellular responses to activation of the thromboxane receptor.[1] Picotamide is licensed in Italy for the treatment of clinical arterial thrombosis and peripheral artery disease.[2]

References[edit]

  1. ^ Ratti, S; Quarato, P; Casagrande, C; Fumagalli, R; Corsini, A (1998). "Picotamide, an antithromboxane agent, inhibits the migration and proliferation of arterial myocytes". European Journal of Pharmacology. 355 (1): 77–83. PMID 9754941. doi:10.1016/S0014-2999(98)00467-1. 
  2. ^ Capra V, Bäck M, Angiolillo DJ, Cattaneo M, Sakariassen KS (2014). "Impact of vascular thromboxane prostanoid receptor activation on hemostasis, thrombosis, oxidative stress, and inflammation". Journal of Thrombosis and Haemostasis : JTH. 12 (2): 126–37. PMID 24298905. doi:10.1111/jth.12472. 

External links[edit]