From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Clinical data
Synonyms Bleomycin A5
  • D
Routes of
intravenous, intraarterial, intramuscular, intratumoral
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Metabolism amidase
Elimination half-life 1.3 hours
Excretion renal (25-50%)
CAS Number
PubChem CID
ECHA InfoCard 100.031.221 Edit this at Wikidata
Chemical and physical data
Formula C57H89N19O21S2
Molar mass 1440.56126
3D model (JSmol)

Pingyangmycin (also known as bleomycin A5) is an antitumor glycopeptide antibiotic belonging to the bleomycin family, which is produced by Streptomyces verticillus var. pingyangensis n.sp., a variety of Streptomyces verticillus. It was discovered in 1969 at Pingyang County of Zhejiang Province in China, and was brought into clinical use in 1978.[1]

In China, pingyangmycin has largely superseded bleomycin A2 (commonly known as "bleomycin"), since it is more effective, costs less, is easier to get, can treat a larger variety of cancers (such as breast cancer and liver cancer) and causes less lung injury.[2][3] Though it also results in pulmonary fibrosis, unlike bleomycin, its most serious side effect is anaphylactic shock, which is rare, but may happen even in a low dose, and can be fatal.[4] In addition, it causes a higher incidence of fever than bleomycin; the occurrence of this complication in patients is between 20 and 50%.


  1. ^ Lin, F. T.; Li, D. D.; Yang, X. P.; Li, Q.; Xue, Y. C.; Zhen, Y. S. (1979). "Antitumor activity and preclinical pharmacologic evaluation of pingyangmycin (author's transl)". Zhonghua zhong liu za zhi \Chinese journal of oncology]. 1 (3): 161–166. PMID 95444. 
  2. ^ Zheng, J. W.; Yang, X. J.; Wang, Y. A.; He, Y.; Ye, W. M.; Zhang, Z. Y. (2009). "Intralesional injection of Pingyangmycin for vascular malformations in oral and maxillofacial regions: An evaluation of 297 consecutive patients". Oral Oncology. 45 (10): 872–876. doi:10.1016/j.oraloncology.2009.02.011. PMID 19628423. 
  3. ^ Xu, H. Z.; Zhang, H. Y. (1980). "The isolation and identification of pingyangmycin (author's transl)". Yao xue xue bao = Acta pharmaceutica Sinica. 15 (10): 609–614. PMID 6167140. 
  4. ^ Shou, B. Q.; Mao, Z.; Zhang, S. L.; Yang, Z. (2009). "Allergy caused by minidose and low concentration Pingyangmycin: A case report". Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology. 27 (5): 572–573. PMID 19927737.