Piperaquine

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Piperaquine
Piperaquine.png
Clinical data
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
Chemical and physical data
Formula C29H32Cl2N6
Molar mass 535.51 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

Piperaquine is an antimalarial drug, a bisquinoline first made in the 1960s, and used extensively in China and Indochina as prophylaxis and treatment during the next 20 years. Usage declined in the 1980s as piperaquine-resistant strains of P. falciparum arose and artemisinin-based antimalarials became available. However, Chinese scientists have been studying whether piperaquine can still be used therapeutically in combination with artemisinin.[1]

Piperaquine is characterized by slow absorption and a long biological half-life,[2] making it a good partner drug with artemisinin derivatives which are fast acting but have a short biological half-life.[3]

The fixed-dose combination dihydroartemisinin-piperaquine (Eurartesim) was submitted for approval to the European Medicines Agency in 2009.[4]

References[edit]

  1. ^ Davis TM, Hung TY, Sim IK, Karunajeewa HA, Ilett KF (2005). "Piperaquine: a resurgent antimalarial drug". Drugs. 65 (1): 75–87. PMID 15610051. doi:10.2165/00003495-200565010-00004. 
  2. ^ D'alessandro U. (2009). "Progress in the development of piperaquine combinations for the treatment of malaria". Curr Opin Infect Dis. 22 (6): 588–92. PMID 19773652. doi:10.1097/QCO.0b013e328332674a. 
  3. ^ http://apps.who.int/prequal/info_applicants/Guidelines/Nonclinical_Overview_Artemisinin-Derivatives.pdf"
  4. ^ Medicines for Malaria. "Registration". Retrieved 2010-06-20.