Platelet-rich fibrin

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Platelet-rich fibrin (PRF) or leucocyte- and platelet-rich fibrin (L-PRF) is a second-generation PRP where autologous platelets and leucocytes are present in a complex fibrin matrix[1][2] to accelerate the healing of soft and hard tissue[3] and is used as a tissue-engineering scaffold for endodontics.[4]


Socket preservation[edit]

Socket preservation, a procedure to reduce bone loss after tooth extraction to preserve the dental alveolus (tooth socket) in the alveolar bone. A platelet-rich fibrin (PRF) membrane containing bone growth enhancing elements can be stitched over the wound or a graft material or scaffold is placed in the socket of an extracted tooth at the time of extraction. The socket is then directly closed with stitches or covered with a non-resorbable or resorbable membrane and sutured.

Sinus lift[edit]

A platelet-rich fibrin can be used if a sinus lift is required for a dental implant.[5][6]

Guided bone and tissue regeneration[edit]

PRF is used in guided bone and tissue regeneration[7]

Regenerative endodontics[edit]

PRF enhances alveolar bone augmentation[8] and necrotic dental pulp and open tooth apex can be revitalized in regenerative endodontics with platelet-rich fibrin.[9]

See also[edit]


  1. ^ Naik B, Karunakar P, Jayadev M, Marshal VR (2013). "Role of Platelet rich fibrin in wound healing: A critical review.". J Conserv Dent. 16 (4): 284–93. doi:10.4103/0972-0707.114344. PMC 3740636Freely accessible. PMID 23956527. 
  2. ^ Dohan Ehrenfest, David M.; Rasmusson, Lars; Albrektsson, Tomas (2009). "Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)". Trends in Biotechnology. 27 (3): 158–167. doi:10.1016/j.tibtech.2008.11.009. ISSN 0167-7799. PMID 19187989. 
  3. ^ Dohan, David M.; Choukroun, Joseph; Diss, Antoine; Dohan, Steve L.; Dohan, Anthony J.J.; Mouhyi, Jaafar; Gogly, Bruno (2006). "Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution". Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 101 (3): e37–e44. doi:10.1016/j.tripleo.2005.07.008. ISSN 1079-2104. 
  4. ^ Hotwani, Kavita; Sharma, Krishna (2014). "Platelet rich fibrin - a novel acumen into regenerative endodontic therapy". Restorative Dentistry & Endodontics. 39 (1): 1. doi:10.5395/rde.2014.39.1.1. ISSN 2234-7658. 
  5. ^ Tajima, Nobutaka; Ohba, Seigo; Sawase, Takashi; Asahina, Izumi (2013). "Evaluation of Sinus Floor Augmentation with Simultaneous Implant Placement Using Platelet-Rich Fibrin as Sole Grafting Material". The International Journal of Oral & Maxillofacial Implants. 28 (1): 77–83. doi:10.11607/jomi.2613. ISSN 0882-2786. 
  6. ^ Simonpieri, Alain; Choukroun, Joseph; Corso, Marco Del; Sammartino, Gilberto; Ehrenfest, David M. Dohan (2011). "Simultaneous Sinus-Lift and Implantation Using Microthreaded Implants and Leukocyte- and Platelet-Rich Fibrin as Sole Grafting Material: A Six-Year Experience". Implant Dentistry. 20 (1): 2–12. doi:10.1097/ID.0b013e3181faa8af. ISSN 1056-6163. PMID 21278521. 
  7. ^ Khiste, Sujeet Vinayak; Naik Tari, Ritam (2013). "Platelet-Rich Fibrin as a Biofuel for Tissue Regeneration". ISRN Biomaterials. 2013: 1–6. doi:10.5402/2013/627367. ISSN 2314-4025. 
  8. ^ Li, Qi; Pan, Shuang; Dangaria, Smit J.; Gopinathan, Gokul; Kolokythas, Antonia; Chu, Shunli; Geng, Yajun; Zhou, Yanmin; Luan, Xianghong (2013). "Platelet-Rich Fibrin Promotes Periodontal Regeneration and Enhances Alveolar Bone Augmentation". BioMed Research International. 2013: 1–13. doi:10.1155/2013/638043. ISSN 2314-6133. 
  9. ^ Johns, DextonAntony; Vidyanath, S; Kumar, MRamesh; Shivashankar, VasundaraYayathi (2012). "Platelet Rich Fibrin in the revitalization of tooth with necrotic pulp and open apex". Journal of Conservative Dentistry. 15 (4): 395–8. doi:10.4103/0972-0707.101926. ISSN 0972-0707. PMID 23112492.