Plexin

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A plexin is a protein which acts as a receptor for semaphorin,.[1][2] Plexin acts as a signal transduction molecule in the neuropilin-plexin receptor complex.[3] Plexins also act as transduction factors for ITAM-DAP12-RANKL signalling pathway involved in osteoclastic differentiation. Genes include:

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References[edit]

  1. ^ Winberg ML, Noordermeer JN, Tamagnone L, et al. (1998). "Plexin A is a neuronal semaphorin receptor that controls axon guidance". Cell. 95 (7): 903–16. doi:10.1016/S0092-8674(00)81715-8. PMID 9875845. 
  2. ^ Kong Y, Janssen BJ, Malinauskas T, Vangoor VR, Coles CH, Kaufmann R, Ni T, Gilbert RJ, Padilla-Parra S, Pasterkamp RJ, Jones EY (2016). "Structural Basis for Plexin Activation and Regulation". Neuron. 91 (8): 1–13. doi:10.1016/j.neuron.2016.06.018. PMID 27397516. 
  3. ^ Janssen BJ, Malinauskas T, Weir GA, Cader MZ, Siebold C, Jones EY (2012). "Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex". Nature Structural & Molecular Biology. 19 (12): 1293–1299. doi:10.1038/nsmb.2416. PMC 3590443Freely accessible. PMID 23104057.