As a young pianist, she has given performances around the world, including at the Sydney Opera House, and other venues in Europe and Japan. She also has occasional honorary starring roles in Thai soap operas, dramas and musicals. A socialite, she is also an occasional model for Thai fashion magazines and society publications.
Ploypailin married her long-time boyfriend David Wheeler at Hawaii, United States on 25 August 2009. The couple have two sons, Maximus "Max" Wheeler and Leonardo "Leo" Wheeler.