Pluronic P-123

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Pluronic P-123
Pluronic P-123 structure.png
IUPAC name
Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)
Other names
PEG-PPG-PEG,Pluronic® P-123
Molar mass ~5800g/mol
Appearance powder
Density 1.018 g/mL at 25 °C
Melting point -24,99 °C at 1.013 hPa
Boiling point > 149 °C
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
The structure of Pluronic P-123,where x=20, y=70, z=20.

Pluronic P123(PEG-PPG-PEG) symmetric triblock copolymer constitutes of poly(ethylene oxide)(PEO) and poly (propylene oxide) (PPO). The unique characteristic of PPO block exhibiting hydrophobicity at temperatures above 288K and solubility in water at temperatures below 288K lead to formation of micelle consisting of PEO-PPO-PEO triblock copolymers. Some studies report that the hydrophobic core contains PPO block, and a hydrophilic corona consists of PEO block. In 30wt% aqueous solution Pluronic P123® forms a cubic gel phase.

Pluronic P-123 is the tradename for a triblock copolymer manufactured by the BASF Corporation. The nominal chemical formula is HO(CH2CH2O)20(CH2CH(CH3)O)70(CH2CH2O)20H, which corresponds to a molecular weight of around 5800 g/mol. Triblock copolymers based on poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) are known generically as poloxamer, and similar materials are manufactured by other companies.

Poloxamers have behaviors similar to those of hydrocarbon surfactants, and will form micelles when placed in a selective solvent such as water. They are capable of forming both spherical and cylindrical micelles [1]


P-123 has recently been used in the synthesis of mesoporous materials including FDU-14.[2] Dissolved P-123 forms micelles that are used as the backbone to make structured mesoporous materials such as SBA-15.

"Potential Degradation by Sonication" Wang et al. reported that aqueous solutions of poloxamer 188 (Pluronic® F-68) and poloxamer 407 (Pluronic® F-127) sonicated in the presence or absence of multi-walled carbon nanotubes (MWNTs) can become highly toxic to cultured cells. Moreover, toxicity correlated with the sonolytic degradation of the polymers.[3]


  1. ^ Wanka, G; Hoffmann, H; Ulbricht, W (1994). "Phase-Diagrams and Aggregation Behavior of Poly(Oxyethylene)-Poly(Oxypropylene)-Poly(Oxyethylene) Triblock Copolymers in Aqueous-Solutions". Macromolecules. 27: 4145–4159. Bibcode:1994MaMol..27.4145W. doi:10.1021/ma00093a016. 
  2. ^ Wan, Y; Zhao, D (2007). "On the Controllable Soft-Templating Approach to Mesoporous Silicates". Chem. Rev. 107: 2821–2860. doi:10.1021/cr068020s. 
  3. ^ Wang, R; Hughes, T; Beck, S; Vakil, S; Li, S; Pantano, P; Draper, RK (2013). "Generation of toxic degradation products by sonication of Pluronic® dispersants: implications for nanotoxicity testing". Nanotoxicology. 7: 1272–81. doi:10.3109/17435390.2012.736547. PMC 3657567Freely accessible. PMID 23030523.