Poly(A)-specific ribonuclease

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PARN
Protein PARN PDB 1whv.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PARN, DAN, DKCB6, PFBMFT4, Poly(A)-specific ribonuclease
External IDs MGI: 1921358 HomoloGene: 31098 GeneCards: PARN
RNA expression pattern
PBB GE PARN 203905 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001134477
NM_001242992
NM_002582

NM_028761

RefSeq (protein)

NP_001127949
NP_001229921
NP_002573

NP_083037

Location (UCSC) Chr 16: 14.44 – 14.63 Mb Chr 16: 13.54 – 13.67 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Poly(A)-specific ribonuclease (PARN), also known as polyadenylate-specific ribonuclease or deadenylating nuclease (DAN), is an enzyme that in humans is encoded by the PARN gene.[3][4]

Function[edit]

Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. The amino acid sequence of poly(A)-specific ribonuclease shows homology to the RNase D family of 3'-exonucleases. The protein appears to be localized in both the nucleus and the cytoplasm. It is not stably associated with polysomes or ribosomal subunits.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Buiting K, Korner C, Ulrich B, Wahle E, Horsthemke B (May 2000). "The human gene for the poly(A)-specific ribonuclease (PARN) maps to 16p13 and has a truncated copy in the Prader-Willi/Angelman syndrome region on 15q11→q13". Cytogenet Cell Genet. 87 (1–2): 125–31. PMID 10640832. doi:10.1159/000015378. 
  4. ^ a b "Entrez Gene: PARN poly(A)-specific ribonuclease (deadenylation nuclease)". 

Further reading[edit]