Poly(beta-D-mannuronate) lyase

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poly(beta-D-mannuronate) lyase
Identifiers
EC number 4.2.2.3
CAS number 9024-15-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Alginate_lyase2
PDB 1vav EBI.jpg
crystal structure of alginate lyase pa1167 from pseudomonas aeruginosa at 2.0 a resolution
Identifiers
Symbol Alginate_lyase2
Pfam PF08787
InterPro IPR014895
SCOP 1uai
SUPERFAMILY 1uai
Alginate_lyase
Identifiers
Symbol Alginate_lyase
Pfam PF05426
SCOP 1uai
SUPERFAMILY 1uai

In enzymology, a poly(beta-D-mannuronate) lyase (EC 4.2.2.3) is an enzyme that catalyzes the chemical reaction

Eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on polysaccharides. The systematic name of this enzyme class is poly(beta-D-1,4-mannuronide) lyase. Other names in common use include alginate lyase I, alginate lyase, alginase I, alginase II, and alginase. This enzyme participates in fructose and mannose metabolism.

Structural studies[edit]

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1HV6, 1J1T, and 2CWS.

References[edit]

  • Davidson IW, Lawson CJ, Sutherland IW (1977). "An alginate lysate from Azotobacter vinelandii phage". J. Gen. Microbiol. 98 (1): 223–9. doi:10.1099/00221287-98-1-223. PMID 13144. 
  • Nakada HI, Sweeny PC (1967). "Alginic acid degradation by eliminases from abalone hepatopancreas". J. Biol. Chem. 242 (5): 845–51. PMID 6020438. 
  • Preiss J; Ashwell G (1962). "Alginic acid metabolism in bacteria. I. Enzymatic formation of unsaturated oligosaccharides and 4-deoxy-L-erythro-5-hexoseulose uronic acid". J. Biol. Chem. 237: 309–316.