Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Polyaminopropyl biguanide (PAPB) is a disinfectant and a preservative used for disinfection on skin and in cleaning solutions for contact lenses. It is also an ingredient in many deodorant bodysprays. It is a polymer or oligomer where biguanide functional groups are connected by hexyl hydrocarbon chains, with varying chain lengths. PAPB is specifically bactericidal at very low concentrations (10 mg/l) and is also fungicidal.
It has a unique method of action: the polymer strands are incorporated into the bacterial cell membrane, which disrupts the membrane and reduces its permeability, which has a lethal effect to bacteria. It is also known to bind to bacterial DNA, alter its transcription, and cause lethal DNA damage.
PAPB solutions are sold for use as a general disinfectant solution to be applied onto skin. As it is not cytotoxic, it can be applied directly into wounds. It is also not irritating like more traditional disinfectants such as alcohols (ethanol, isopropanol) and oxidizers (iodine).
Contact lens solution
A contact lens solution containing polyaminopropyl biguanide in combination with a borate buffer has been patented. The solution is disinfecting and preservative and has a broad spectrum of bactericidal and fungicidal activity at low concentrations coupled with very low toxicity when used with soft-type contact lenses.
- Antimicrobial resistance
- Polyhexanide, a related biguanide disinfectant
- Benzalkonium chloride
- Stearalkonium chloride
- Ethylenediaminetetraacetic acid
- Allen; White, GF; Morby, AP; et al. (2006). "The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide". Microbiology. 152 (4): 989–1000. doi:10.1099/mic.0.28643-0. PMID 16549663.
- Gerit D. Mulder, Joseph P. Cavorsi and Daniel K. Lee (2007). "Polyhexamethylene Biguanide (PHMB): An Addendum to Current Topical Antimicrobials". Wounds. 19 (7): 173–182.
- Ogunbiyi et al. US 4758595
- Josefa Velasco, Javier Bermudez (1996). "Comparative study of the microbial flora on contact lenses, in lens cases, and in maintenance liquids". Contact Lens and Anterior Eye. 23 (2): 55–58. doi:10.1016/0892-8967(96)00004-1.