Polyaminopropyl biguanide

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Polyaminopropyl biguanide
Polyaminopropyl biguanide.svg
Names
Other names
Polyamine-propyl-biguanidine
Identifiers
133029-32-0 N
Abbreviations PAPB
ChemSpider  YesY
Properties
(C5H11N5)n
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

Polyaminopropyl biguanide (PAPB) is a disinfectant and a preservative used for disinfection on skin and in cleaning solutions for contact lenses.[citation needed] It is also an ingredient in many deodorant bodysprays.[citation needed] It is a polymer or oligomer where biguanide functional groups are connected by hexyl hydrocarbon chains, with varying chain lengths.[citation needed] PAPB is specifically bactericidal at very low concentrations (10 mg/l) and is also fungicidal.[citation needed]

Biocidal activity[edit]

It has a unique method of action: the polymer strands are incorporated into the bacterial cell membrane, which disrupts the membrane and reduces its permeability, which has a lethal effect to bacteria. It is also known to bind to bacterial DNA, alter its transcription, and cause lethal DNA damage.[1] It has very low toxicity to higher organisms such as human cells, which have more complex and protective membranes.[citation needed] PAPB is a mixture of molecules of various sizes; different-size molecules have a synergistic effect.[citation needed]

Disinfectant[edit]

PAPB solutions are sold for use as a general disinfectant solution to be applied onto skin. As it is not cytotoxic, it can be applied directly into wounds.[2] It is also not irritating like more traditional disinfectants such as alcohols (ethanol, isopropanol) and oxidizers (iodine).

Contact lens solution[edit]

A contact lens solution containing polyaminopropyl biguanide in combination with a borate buffer has been patented.[3] The solution is disinfecting and preservative and has a broad spectrum of bactericidal and fungicidal activity at low concentrations coupled with very low toxicity when used with soft-type contact lenses.[4]

Clothing treatment[edit]

Purista is a PHMB-based preparation that is added to socks to slow the development of body odor.[citation needed] By adding microbicides to textiles in such a manner that they are slowly released to the local environment, bacteria and fungi sensitive to the microbicide can be killed in proximity to the textiles; this may slow down processes that depend on the microorganisms, such as the development of body odor.[citation needed]

See also[edit]

References[edit]

  1. ^ Allen; White, GF; Morby, AP et al. (2006). "The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide". Microbiology (Reading, England) 152 (4): 989–1000. doi:10.1099/mic.0.28643-0. PMID 16549663. 
  2. ^ Gerit D. Mulder, Joseph P. Cavorsi and Daniel K. Lee (2007). Wounds 19 (7): 173–182 http://www.medscape.com/viewarticle/561512.  Missing or empty |title= (help)
  3. ^ Ogunbiyi et al. US 4758595 
  4. ^ Josefa Velasco, Javier Bermudez (1996). "Comparative study of the microbial flora on contact lenses, in lens cases, and in maintenance liquids". Contact Lens and Anterior Eye 23 (2): 55–58. doi:10.1016/0892-8967(96)00004-1.