Polyene antimycotics, sometimes referred to as polyene antibiotics, are a class of antimicrobial polyene compounds that target fungi. These polyene antimycotics are typically obtained from some species of Streptomyces bacteria. The polyenes bind to ergosterol in the fungal cell membrane and thus weakens it, causing leakage of K+ and Na+ ions, which may contribute to fungal cell death. Amphotericin B, nystatin, and natamycin are examples of polyene antimycotics. They are a subgroup of macrolides.
Their chemical structures feature a large ring of atoms (in essence, a cyclic ester ring) containing multiple conjugated carbon-carbon double bonds (hence polyene) on one side of the ring and multiple hydroxyl groups bonded to the other side of the ring. Their structures also often have a d-mycosamine (a type of amino-glycoside) group bonded to the molecule. The series of conjugated double bonds typically absorbs strongly in the ultraviolet-visible region of the electromagnetic spectrum, often resulting in the polyene antibiotics having a yellow color.
Other examples of polyenes
- "Antifungal Agents". Polyene Antifungal Drugs. NCBI Bookshelf. The University of Texas Medical Branch at Galveston. 1996. ISBN 9780963117212. Retrieved 29 January 2010.
- Hamilton-Miller (1973). "Chemistry and Biology of the Polyene Macrolide Antibiotics". Bacteriological Reviews. American Society for Microbiology. 37 (2): 166–196. PMC 413810. PMID 4578757.
- Volpon, Laurent; Lancelin, Jean-Marc (2002). "Solution NMR structure of five representative glycosylated polyene macrolide antibiotics with a sterol-dependent antifungal activity". European Journal of Biochemistry. 269 (18): 4533–4541. doi:10.1046/j.1432-1033.2002.03147.x.
- Khan N, Rawlings B, Caffrey P (Jan 26, 2011). "A labile point in mutant amphotericin polyketide synthases". Biotechnol. Lett. 33 (6): 1121–6. doi:10.1007/s10529-011-0538-3. PMID 21267757.
|This antiinfective drug article is a stub. You can help Wikipedia by expanding it.|