Polymeric immunoglobulin receptor

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Protein PIGR PDB 1xed.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases PIGR, Pigr, polymeric immunoglobulin receptor
External IDs MGI: 103080 HomoloGene: 1984 GeneCards: PIGR
RNA expression pattern
PBB GE PIGR 204213 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 206.93 – 206.95 Mb Chr 1: 130.83 – 130.85 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Polymeric immunoglobulin receptor (pIgR) is a protein that in humans is encoded by the PIGR gene.[3] It is a Fc receptor which facilitates the secretion of the soluble polymeric isoforms of immunoglobulin A and immunoglobulin M.


pIgR is expressed on several glandular epithelia including those of liver and breast. It mediates transcellular transport of polymeric immunoglobulin molecules. It is a member of the immunoglobulin superfamily.[3][4]


The receptor has five domians with homology to the immunoglobulin fold plus a transmembrane region,[5] which also has some homology to certain immunoglobulin variable regions.[3]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b c "Entrez Gene: PIGR polymeric immunoglobulin receptor". 
  4. ^ Hood L, Kronenberg M, Hunkapiller T (Feb 1985). "T cell antigen receptors and the immunoglobulin supergene family". Cell. 40 (2): 225–9. doi:10.1016/0092-8674(85)90133-3. PMID 3917857. 
  5. ^ Woof, J. M.; Russell, M. W. (2011-11-01). "Structure and function relationships in IgA". Mucosal Immunology. 4 (6): 590–597. doi:10.1038/mi.2011.39. ISSN 1933-0219. 

Further reading[edit]

  • Kaetzel CS (Aug 2005). "The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces". Immunological Reviews. 206: 83–99. doi:10.1111/j.0105-2896.2005.00278.x. PMID 16048543. 
  • Krajci P, Kvale D, Taskén K, Brandtzaeg P (Sep 1992). "Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor)". European Journal of Immunology. 22 (9): 2309–15. doi:10.1002/eji.1830220920. PMID 1355431. 
  • Krajci P, Grzeschik KH, Geurts van Kessel AH, Olaisen B, Brandtzaeg P (Oct 1991). "The human transmembrane secretory component (poly-Ig receptor): molecular cloning, restriction fragment length polymorphism and chromosomal sublocalization". Human Genetics. 87 (6): 642–8. doi:10.1007/BF00201717. PMID 1682231. 
  • Eiffert H, Quentin E, Wiederhold M, Hillemeir S, Decker J, Weber M, Hilschmann N (Feb 1991). "Determination of the molecular structure of the human free secretory component". Biological Chemistry Hoppe-Seyler. 372 (2): 119–28. doi:10.1515/bchm3.1991.372.1.119. PMID 1859628. 
  • Bakos MA, Kurosky A, Goldblum RM (Nov 1991). "Characterization of a critical binding site for human polymeric Ig on secretory component". Journal of Immunology. 147 (10): 3419–26. PMID 1940346. 
  • Krajci P, Solberg R, Sandberg M, Oyen O, Jahnsen T, Brandtzaeg P (Feb 1989). "Molecular cloning of the human transmembrane secretory component (poly-Ig receptor) and its mRNA expression in human tissues". Biochemical and Biophysical Research Communications. 158 (3): 783–9. doi:10.1016/0006-291X(89)92790-3. PMID 2920039. 
  • Davidson MK, Le Beau MM, Eddy RL, Shows TB, DiPietro LA, Kingzette M, Hanly WC (1989). "Genetic mapping of the human polymeric immunoglobulin receptor gene to chromosome region 1q31----q41". Cytogenetics and Cell Genetics. 48 (2): 107–11. doi:10.1159/000132601. PMID 3197448. 
  • Eiffert H, Quentin E, Decker J, Hillemeir S, Hufschmidt M, Klingmüller D, Weber MH, Hilschmann N (Dec 1984). "[The primary structure of human free secretory component and the arrangement of disulfide bonds]". Hoppe-Seyler's Zeitschrift für Physiologische Chemie. 365 (12): 1489–95. PMID 6526384. 
  • Mizoguchi A, Mizuochi T, Kobata A (Aug 1982). "Structures of the carbohydrate moieties of secretory component purified from human milk". The Journal of Biological Chemistry. 257 (16): 9612–21. PMID 7107583. 
  • Coyne RS, Siebrecht M, Peitsch MC, Casanova JE (Dec 1994). "Mutational analysis of polymeric immunoglobulin receptor/ligand interactions. Evidence for the involvement of multiple complementarity determining region (CDR)-like loops in receptor domain I". The Journal of Biological Chemistry. 269 (50): 31620–5. PMID 7989333. 
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Piskurich JF, France JA, Tamer CM, Willmer CA, Kaetzel CS, Kaetzel DM (Mar 1993). "Interferon-gamma induces polymeric immunoglobulin receptor mRNA in human intestinal epithelial cells by a protein synthesis dependent mechanism". Molecular Immunology. 30 (4): 413–21. doi:10.1016/0161-5890(93)90071-I. PMID 8455639. 
  • Piskurich JF, Youngman KR, Phillips KM, Hempen PM, Blanchard MH, France JA, Kaetzel CS (Jan 1997). "Transcriptional regulation of the human polymeric immunoglobulin receptor gene by interferon-gamma". Molecular Immunology. 34 (1): 75–91. doi:10.1016/S0161-5890(96)00079-X. PMID 9182878. 
  • Hughes GJ, Frutiger S, Savoy LA, Reason AJ, Morris HR, Jaton JC (Jun 1997). "Human free secretory component is composed of the first 585 amino acid residues of the polymeric immunoglobulin receptor". FEBS Letters. 410 (2-3): 443–6. doi:10.1016/S0014-5793(97)00629-7. PMID 9237679. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Ackermann LW, Wollenweber LA, Denning GM (May 1999). "IL-4 and IFN-gamma increase steady state levels of polymeric Ig receptor mRNA in human airway and intestinal epithelial cells". Journal of Immunology. 162 (9): 5112–8. PMID 10227981. 
  • Røe M, Norderhaug IN, Brandtzaeg P, Johansen FE (May 1999). "Fine specificity of ligand-binding domain 1 in the polymeric Ig receptor: importance of the CDR2-containing region for IgM interaction". Journal of Immunology. 162 (10): 6046–52. PMID 10229845. 
  • Norderhaug IN, Johansen FE, Krajci P, Brandtzaeg P (Oct 1999). "Domain deletions in the human polymeric Ig receptor disclose differences between its dimeric IgA and pentameric IgM interaction". European Journal of Immunology. 29 (10): 3401–9. doi:10.1002/(SICI)1521-4141(199910)29:10<3401::AID-IMMU3401>3.0.CO;2-G. PMID 10540352. 
  • Mostov KE, Friedlander M, Blobel G (1984). "The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains". Nature. 308 (5954): 37–43. doi:10.1038/308037a0. PMID 6322002. 
  • Hughes GJ, Reason AJ, Savoy L, Jaton J, Frutiger-Hughes S (Sep 1999). "Carbohydrate moieties in human secretory component". Biochimica et Biophysica Acta. 1434 (1): 86–93. doi:10.1016/S0167-4838(99)00168-5. PMID 10556562. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.