Polymeric immunoglobulin receptor

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Polymeric immunoglobulin receptor
Protein PIGR PDB 1xed.png
PDB rendering based on 1xed.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PIGR ; FLJ22667; MGC125361; MGC125362
External IDs OMIM173880 MGI103080 HomoloGene1984 GeneCards: PIGR Gene
RNA expression pattern
PBB GE PIGR 204213 at tn.png
More reference expression data
Species Human Mouse
Entrez 5284 18703
Ensembl ENSG00000162896 ENSMUSG00000026417
UniProt P01833 O70570
RefSeq (mRNA) NM_002644 NM_011082
RefSeq (protein) NP_002635 NP_035212
Location (UCSC) Chr 1:
207.1 – 207.12 Mb
Chr 1:
130.83 – 130.85 Mb
PubMed search [1] [2]

Polymeric immunoglobulin receptor is a protein that in humans is encoded by the PIGR gene.[1] It is a Fc receptor which facilitates the secretion of the soluble polymeric isoforms of immunoglobulin A and immunoglobulin M.

The poly-Ig receptor is expressed on several glandular epithelia including those of liver and breast. It mediates transcellular transport of polymeric immunoglobulin molecules. It is a member of the immunoglobulin superfamily (Hood et al., 1985). The receptor has 5 units with homology to the variable (V) units of immunoglobulins and a transmembrane region, which also has some homology to certain immunoglobulin variable regions.[supplied by OMIM][1]


Further reading[edit]

  • Kaetzel CS (2005). "The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces.". Immunol. Rev. 206: 83–99. doi:10.1111/j.0105-2896.2005.00278.x. PMID 16048543. 
  • Krajci P, Kvale D, Taskén K, Brandtzaeg P (1992). "Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor)". Eur. J. Immunol. 22 (9): 2309–15. doi:10.1002/eji.1830220920. PMID 1355431. 
  • Krajci P, Grzeschik KH, Geurts van Kessel AH et al. (1991). "The human transmembrane secretory component (poly-Ig receptor): molecular cloning, restriction fragment length polymorphism and chromosomal sublocalization.". Hum. Genet. 87 (6): 642–8. doi:10.1007/BF00201717. PMID 1682231. 
  • Eiffert H, Quentin E, Wiederhold M et al. (1991). "Determination of the molecular structure of the human free secretory component.". Biol. Chem. Hoppe-Seyler 372 (2): 119–28. doi:10.1515/bchm3.1991.372.1.119. PMID 1859628. 
  • Bakos MA, Kurosky A, Goldblum RM (1991). "Characterization of a critical binding site for human polymeric Ig on secretory component". J. Immunol. 147 (10): 3419–26. PMID 1940346. 
  • Krajci P, Solberg R, Sandberg M et al. (1989). "Molecular cloning of the human transmembrane secretory component (poly-Ig receptor) and its mRNA expression in human tissues". Biochem. Biophys. Res. Commun. 158 (3): 783–9. doi:10.1016/0006-291X(89)92790-3. PMID 2920039. 
  • Davidson MK, Le Beau MM, Eddy RL et al. (1989). "Genetic mapping of the human polymeric immunoglobulin receptor gene to chromosome region 1q31----q41". Cytogenet. Cell Genet. 48 (2): 107–11. doi:10.1159/000132601. PMID 3197448. 
  • Hood L, Kronenberg M, Hunkapiller T (1985). "T cell antigen receptors and the immunoglobulin supergene family". Cell 40 (2): 225–9. doi:10.1016/0092-8674(85)90133-3. PMID 3917857. 
  • Eiffert H, Quentin E, Decker J et al. (1985). "[The primary structure of human free secretory component and the arrangement of disulfide bonds]". Hoppe-Seyler's Z. Physiol. Chem. 365 (12): 1489–95. PMID 6526384. 
  • Mizoguchi A, Mizuochi T, Kobata A (1982). "Structures of the carbohydrate moieties of secretory component purified from human milk". J. Biol. Chem. 257 (16): 9612–21. PMID 7107583. 
  • Coyne RS, Siebrecht M, Peitsch MC, Casanova JE (1995). "Mutational analysis of polymeric immunoglobulin receptor/ligand interactions. Evidence for the involvement of multiple complementarity determining region (CDR)-like loops in receptor domain I". J. Biol. Chem. 269 (50): 31620–5. PMID 7989333. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Piskurich JF, France JA, Tamer CM et al. (1993). "Interferon-gamma induces polymeric immunoglobulin receptor mRNA in human intestinal epithelial cells by a protein synthesis dependent mechanism". Mol. Immunol. 30 (4): 413–21. doi:10.1016/0161-5890(93)90071-I. PMID 8455639. 
  • Piskurich JF, Youngman KR, Phillips KM et al. (1997). "Transcriptional regulation of the human polymeric immunoglobulin receptor gene by interferon-gamma". Mol. Immunol. 34 (1): 75–91. doi:10.1016/S0161-5890(96)00079-X. PMID 9182878. 
  • Hughes GJ, Frutiger S, Savoy LA et al. (1997). "Human free secretory component is composed of the first 585 amino acid residues of the polymeric immunoglobulin receptor". FEBS Lett. 410 (2–3): 443–6. doi:10.1016/S0014-5793(97)00629-7. PMID 9237679. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Ackermann LW, Wollenweber LA, Denning GM (1999). "IL-4 and IFN-gamma increase steady state levels of polymeric Ig receptor mRNA in human airway and intestinal epithelial cells". J. Immunol. 162 (9): 5112–8. PMID 10227981. 
  • Røe M, Norderhaug IN, Brandtzaeg P, Johansen FE (1999). "Fine specificity of ligand-binding domain 1 in the polymeric Ig receptor: importance of the CDR2-containing region for IgM interaction". J. Immunol. 162 (10): 6046–52. PMID 10229845. 
  • Norderhaug IN, Johansen FE, Krajci P, Brandtzaeg P (1999). "Domain deletions in the human polymeric Ig receptor disclose differences between its dimeric IgA and pentameric IgM interaction". European Journal of Immunology 29 (10): 3401–9. doi:10.1002/(SICI)1521-4141(199910)29:10<3401::AID-IMMU3401>3.0.CO;2-G. PMID 10540352. 
  • Mostov KE, Friedlander M, Blobel G. (1984). "The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains". Nature 308 (5954): 37–43. doi:10.1038/308037a0. PMID 6322002. 
  • Hughes GJ, Reason AJ, Savoy L et al. (1999). "Carbohydrate moieties in human secretory component". Biochim. Biophys. Acta 1434 (1): 86–93. doi:10.1016/S0167-4838(99)00168-5. PMID 10556562. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.