Polynucleotide 5'-phosphatase

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polynucleotide 5'-phosphatase
Identifiers
EC number 3.1.3.33
CAS number 37288-17-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a polynucleotide 5'-phosphatase (EC 3.1.3.33) is an enzyme that catalyzes the chemical reaction

a 5'-phosphopolynucleotide + H2O a polynucleotide + phosphate

Thus, the two substrates of this enzyme are 5'-phosphopolynucleotide and H2O, whereas its two products are polynucleotide and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is polynucleotide 5'-phosphohydrolase. This enzyme is also called 5'-polynucleotidase.

Structural studies[edit]

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1D8H, 1D8I, 1I9S, 1I9T, and 1YN9.

References[edit]

  • Becker A, Hurwitz J (1967). "The enzymatic cleavage of phosphate termini from polynucleotides". J. Biol. Chem. 242 (5): 936–50. PMID 4289819.