Polyostotic fibrous dysplasia

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Polyostotic fibrous dysplasia
Other namesAlbright's disease[1]:578

Polyostotic fibrous dysplasia is a form of fibrous dysplasia affecting more than one bone.[2] Fibrous dysplasia is a disorder where bone is replaced by fibrous tissue, leading to weak bones, uneven growth, and deformity. [3]

McCune-Albright syndrome includes polyostotic fibrous dysplasia as part of its presentation.[4] When polyostotic fibrous dysplasia manifests in the long bones, limping results; when it manifests in the face, asymmetric growth of the face can result.[3]

One treatment that has been used is bisphosphonates.[5]

See also[edit]


  1. ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
  2. ^ "Fibrous Dysplasia: Overview - eMedicine Radiology". Retrieved 2009-02-23.
  3. ^ a b Reference, Genetics Home. "McCune-Albright syndrome". Genetics Home Reference. Retrieved 2018-10-30.
  4. ^ Lee, Peter A. (5 December 1986). "McCune-Albright Syndrome: Long-term Follow-up". JAMA: The Journal of the American Medical Association. 256 (21): 2980. doi:10.1001/jama.1986.03380210076028.
  5. ^ Khadilkar VV, Khadilkar AV, Maskati GB (September 2003). "Oral bisphosphonates in polyostotic fibrous dysplasia". Indian Pediatr. 40 (9): 894–6. PMID 14530553.

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