At the time of the primaries, incumbent Governor Aníbal Acevedo Vilá was allegedly being investigated by federal authorities for allegations of irregularities in his campaign finances. However, despite this, the party supported his candidacy for Governor.
Also, one of the most contested campaigns was the one for Mayor of Ponce, with incumbent Francisco Zayas Seijo facing the former administrator of the city, Carlos Jirau.
Several weeks after the primaries, Incumbent Governor and PPD candidate, Aníbal Acevedo Vilá, was officially indicted on 19 counts of campaign finance violations. This put his candidacy in jeopardy, and several candidates where taunted as possible replacements. However, Acevedo Vilá decided to run for reelection, and was openly endorsed by the Party in a massive caucus held at the José Miguel Agrelot Coliseum on April 2008. Acevedo Vilá would lose the 2008 general elections. However, on March 2009, he was found not guilty of all charges by a jury.
In the primary for the Mayor of Ponce, incumbent Francisco Zayas Seijo narrowly beat his opponent, former Ponce administrator, Carlos Jirau. Zayas beat Jirau by less than 30 votes. After the defeat, Jirau appealed the primary claiming there were irregularities in the process. He also started an independent movement called Movimiento Autónomo Ponceño. At the 2008 general elections, both Zayas and Jirau were defeated by the PNP candidate Mayita Meléndez. This was the first time a PNP candidate had won in Ponce in more than 20 years.