The Great Western Railway opened the first railway station in Port Credit in 1855 at Stavebank Road, just west of the current GO Transit facility. That station burned to the ground and was replaced by Canadian National closer to the location of the current station, which opened in 1967 when GO Train service began on the Lakeshore West line. The Great Western Railway was purchased in 1882 by the Grand Trunk Railway, which was absorbed into the Canadian National Railway in 1920.
Port Credit GO has been identified by Metrolinx as a transportation mobility hub, where different forms of transportation come together, serving as the origin, destination or transfer point for a significant amount of trips. It also is a concentrated point of employment, housing, and recreation, making them places of significant economic development and activity where office buildings, hospitals, educational institutions, government service and information centres, shopping malls and restaurants can be located.