, sold under the brand name Solian
among others, is an antipsychotic
medication used to treat schizophrenia
. It is also used to treat dysthymia
. It is usually classed with the atypical antipsychotics
. Chemically it is a benzamide
and like other benzamide antipsychotics, such as sulpiride
, it is associated with a high risk of elevating blood levels of the lactation hormone, prolactin
(thereby potentially causing the absence of the menstrual cycle
, breast enlargement, even in males, breast milk secretion not related to breastfeeding
, impaired fertility, impotence
, breast pain, etc.
), and a low risk, relative to the typical antipsychotics
, of causing movement disorders
. It has also been found to be modestly more effective in treating schizophrenia than the typical antipsychotics.
Amisulpride is believed to work by reducing signalling via the dopamine D2 receptor
. In amisulpride's case this is by blocking, or antagonizing, the receptor. Amisulpride's effectiveness in treating dysthymia and the negative symptoms
of schizophrenia is believed to stem from its blockade of the presynaptic
receptors. These presynaptic receptors regulate the release of dopamine
into the synapse
, so by blocking them amisulpride increases dopamine concentrations in the synapse. This increased dopamine concentration is theorized to act on dopamine D1 receptors
to relieve depressive symptoms (in dysthymia) and the negative symptoms of schizophrenia. Read more...