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For a topic outline of science, see Outline of science.

French Academy of Sciences

Science (from the Latin word scientia, meaning "knowledge") is a systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe.

The earliest roots of science can be traced to Ancient Egypt and Mesopotamia in around 3500 to 3000 BCE. Their contributions to mathematics, astronomy, and medicine entered and shaped Greek natural philosophy of classical antiquity, whereby formal attempts were made to provide explanations of events in the physical world based on natural causes. After the fall of the Western Roman Empire, knowledge of Greek conceptions of the world deteriorated in Western Europe during the early centuries (400 to 1000 CE) of the Middle Ages but was preserved in the Muslim world during the Islamic Golden Age. The recovery and assimilation of Greek works and Islamic inquiries into Western Europe from the 10th to 13th century revived natural philosophy, which was later transformed by the Scientific Revolution that began in the 16th century as new ideas and discoveries departed from previous Greek conceptions and traditions. The scientific method soon played a greater role in knowledge creation and it was not until the 19th century that many of the institutional and professional features of science began to take shape.

Modern science is typically divided into three major branches that consist of the natural sciences (e.g., biology, chemistry, and physics), which study nature in the broadest sense; the social sciences (e.g., economics, psychology, and sociology), which study individuals and societies; and the formal sciences (e.g., logic, mathematics, and theoretical computer science), which study abstract concepts. There is disagreement, however, on whether the formal sciences actually constitute a science as they do not rely on empirical evidence. Disciplines that use existing scientific knowledge for practical purposes, such as engineering and medicine, are described as applied sciences.

Science is based on research, which is commonly conducted in academic and research institutions as well as in government agencies and companies. The practical impact of scientific research has led to the emergence of science policies that seek to influence the scientific enterprise by prioritizing the development of commercial products, armaments, health care, and environmental protection.

Selected article

DNA repair refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as UV light can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. Consequently, the DNA repair process must be constantly active so it can respond rapidly to any damage in the DNA structure.

The rate of DNA repair is dependent on many factors, including the cell type, the age of the cell, and the extracellular environment. A cell that has accumulated a large amount of DNA damage, or one that no longer effectively repairs damage incurred by its DNA, can enter one of three possible states: an irreversible state of dormancy, known as senescence; cell suicide, also known as apoptosis or programmed cell death; or unregulated cell division, which can lead to the formation of a tumor that is cancerous.

Selected image

An 18th Century Persian astrolabe used for determining the time at both day and night. The points of the curved spikes on the front rete plate mark the positions of the brightest stars, the name of each star being labeled at the base of each spike. The back plate, or mater, is engraved with projected coordinate lines. From the Whipple Museum of the History of Science collection.

Selected biography

Barbara McClintock (June 16, 1902 – September 2, 1992) was a pioneering American scientist and one of the world's most distinguished cytogeneticists. McClintock received her PhD in botany from Cornell University in 1927, where she was a leader in the development of maize cytogenetics. The field remained the focus of her research for the rest of her career. From the late 1920s, McClintock studied chromosomes and how they change during reproduction in maize. She developed the technique to visualize maize chromosomes and demonstrate genetic recombination by crossing-over during meiosis—a mechanism by which chromosomes exchange information. She produced the first genetic map for maize, and she demonstrated the role of the telomere and centromere. She was awarded prestigious fellowships and elected a member of the National Academy of Sciences in 1944.

Did you know...

• ...that the endangered golden lion tamarin (pictured) has a long, but not prehensile, tail?
• ...that the Witch's hat is the common name of a colourful orange-red toadstool?
• ...that Grandi's series 1 − 1 + 1 − 1 + • • • is divergent and appears to equal 0, yet in some sense "sums" to ¹⁄₂ — a paradox once linked to the creation ex nihilo of the universe?
• ...that Derek Freeman was an anthropologist whose refutation of Margaret Mead's work "ignited controversy of a scale, visibility, and ferocity never before seen in anthropology"?
• ...that the New Year's Eve snowstorm of 1963/1964 dropped over 17 inches of snow at Huntsville, Alabama, simultaneously setting new snowfall records for any day, week, or month in their history?