Postperfusion syndrome

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Postperfusion syndrome, also known as "pumphead", is a constellation of neurocognitive impairments attributed to cardiopulmonary bypass (CPB) during cardiac surgery. Symptoms of postperfusion syndrome are subtle and include defects associated with attention, concentration, short-term memory, fine motor function, and speed of mental and motor responses.[1] Studies have shown a high incidence of neurocognitive deficit soon after surgery, but the deficits are often transient with no permanent neurological impairment.[1][2]


A study by Newman et al. at Duke University Medical Center showed an increased incidence of cognitive decline after coronary artery bypass surgery (CABG), both immediately (53 percent at discharge from hospital) and over time (36 percent six weeks, 24 percent at six months, and 42 percent at five years).[3] This study shows an association of neurocognitive decline with CABG, but does not show causation; the study lacks a control group and is considered level II-3 evidence. Also, the statistical calculation of cognitive decline has been demonstrated as the least reliable due to practice effects, measurement error and the regression to the mean phenomenon.[4]

Subsequent studies have compared "on-pump" CABG to off-pump coronary artery bypass (OPCAB)—essentially establishing controls to compare the incidence of neurocognitive decline in CABG with and without the use of CPB. A small study (60 patients total, 30 in each treatment arm) by Zamvar et al. demonstrated neurocognitive impairment was worse for the on-pump group both 1 week and 10 weeks postoperatively.[5] A larger study (281 patients total) by Van Dijk et al. showed CABG surgery without cardiopulmonary bypass improved cognitive outcomes 3 months after the procedure, but the effects were limited and became negligible at 12 months.[2] Furthermore, the Van Dijk study showed no difference between the on-pump and off-pump groups in quality of life, stroke rate, or all-cause mortality at 3 and 12 months. A study by Jenson et al. published in Circulation found no significant difference in the incidence of cognitive dysfunction 3 months after either OPCAB or conventional on-pump CABG.[1]

Given the above studies, there is high incidence of neurocognitive deficit shortly after bypass surgery, but evidence is less clear about long-term neurological impairment. Controlled "on-pump" versus "off-pump" cardiac surgery has only been studied in the setting of CABG and is not necessarily generalizable to other types of cardiac surgery. Recent advancements in transcatheter and percutaneous valve replacement may soon allow comparison of other types of cardiac surgery with and without CPB.

Neurocognitive deficit as a consequence of vascular disease[edit]

A study by McKhann et al.[6] compared the neurocognitive outcome of people with coronary artery disease (CAD) to heart-healthy controls (people with no cardiac risk factors). People with CAD were subdivided into treatment with CABG, OPCAB and non-surgical medical management. The three groups with CAD all performed significantly lower at baseline than the heart-healthy controls. All groups improved by 3 months, and there were minimal intrasubject changes from 3 to 12 months. No consistent difference between the CABG and off-pump patients was observed. The authors concluded patients with long-standing coronary artery disease have some degree of cognitive dysfunction secondary to cerebrovascular disease before surgery; there is no evidence the cognitive test performance of bypass surgery patients differed from similar control groups with coronary artery disease over a 12-month follow-up period. A related study by Selnes et al.[7] concluded patients with coronary artery bypass grafting did not differ from a comparable nonsurgical control group with coronary artery disease 1 or 3 years after baseline examination. This finding suggests that late cognitive decline after coronary artery bypass grafting previously reported by Newman et al.[3] may not be specific to the use of cardiopulmonary bypass, but may also occur in patients with very similar risk factors for cardiovascular and cerebrovascular disease.[citation needed]

Proposed mechanism[edit]

Physicians have theorized that the syndrome is caused by tiny debris and air bubbles (microemboli) that enter the brain via cardiopulmonary bypass. Surgeons attempt to minimize time spent on bypass to decrease postoperative deficits; studies have shown increased bypass time is associated with increased incidence and severity of postperfusion syndrome[citation needed] and mortality. It is unclear how increases in bypass time would result in such increases if pre-existing cardiovascular and cerebrovascular conditions are the principal causative mechanisms of postperfusion syndrome.[citation needed]

Documentary film[edit]

In 2020, Australian film director Andrew Pike released Pumphead, a documentary about the condition. The film explores the experiences of eight patients following major heart surgery, describing their experiences with postperfusion syndrome. The filmmaker Andrew Pike experienced 'pumphead' himself, following open-heart surgery in 2011.[8] The film introduces the concept of post-traumatic growth, as a positive psychological change that can follow traumatic experiences such as 'pumphead'.[8]

See also[edit]


  1. ^ a b c Jensen B, Hughes P, Rasmussen L, Pedersen P, Steinbrüchel D (2006). "Cognitive outcomes in elderly high-risk patients after off-pump versus conventional coronary artery bypass grafting: a randomized trial". Circulation. 113 (24): 2790–5. doi:10.1161/CIRCULATIONAHA.105.587931. PMID 16769915.
  2. ^ a b Van Dijk D, Jansen E, Hijman R, Nierich A, Diephuis J, Moons K, Lahpor J, Borst C, Keizer A, Nathoe H, Grobbee D, De Jaegere P, Kalkman C (2002). "Cognitive outcome after off-pump and on-pump coronary artery bypass graft surgery: a randomized trial". JAMA. 287 (11): 1405–12. doi:10.1001/jama.287.11.1405. PMID 11903027.
  3. ^ a b Newman M, Kirchner J, Phillips-Bute B, Gaver V, Grocott H, Jones R, Mark D, Reves J, Blumenthal J (2001). "Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery". N Engl J Med. 344 (6): 395–402. doi:10.1056/NEJM200102083440601. PMID 11172175.
  4. ^ Raymond P, Hinton-Bayre A, Radel M, Ray M, Marsh N (2006). "Assessment of statistical change criteria used to define significant change in neuropsychological test performance following cardiac surgery". Eur J Cardiothorac Surg. 29 (1): 82–88. doi:10.1016/j.ejcts.2005.10.016. PMID 16337395.
  5. ^ Zamvar V, Williams D, Hall J, Payne N, Cann C, Young K, Karthikeyan S, Dunne J (2002). "Assessment of neurocognitive impairment after off-pump and on-pump techniques for coronary artery bypass graft surgery: prospective randomised controlled trial". BMJ. 325 (7375): 1268. doi:10.1136/bmj.325.7375.1268. PMC 136922. PMID 12458242.
  6. ^ McKhann G, Grega M, Borowicz L, Bailey M, Barry S, Zeger S, Baumgartner W, Selnes O (2005). "Is there cognitive decline 1 year after CABG? Comparison with surgical and nonsurgical controls". Neurology. 65 (7): 991–9. doi:10.1212/01.wnl.0000175220.78475.99. PMID 16107605. S2CID 21972340.
  7. ^ Selnes O, Grega M, Borowicz L, Barry S, Zeger S, Baumgartner W, McKhann G (2005). "Cognitive outcomes three years after coronary artery bypass surgery: a comparison of on-pump coronary artery bypass graft surgery and nonsurgical controls". Ann Thorac Surg. 79 (4): 1201–9. doi:10.1016/j.athoracsur.2004.10.011. PMID 15797050.
  8. ^ a b "Pumphead Press Kit" (PDF). Ronin Films. 16 October 2020. Retrieved 18 January 2022.

Further reading[edit]