Potassium in biology
Potassium is the main intracellular ion for all types of cells, while having a major role in maintenance of fluid and electrolyte balance. Potassium is necessary for the function of all living cells, and is thus present in all plant and animal tissues. It is found in especially high concentrations within plant cells, and in a mixed diet, it is most highly concentrated in fruits. The high concentration of potassium in plants, associated with comparatively very low amounts of sodium there, historically resulted in potassium first being isolated from the ashes of plants (potash), which in turn gave the element its modern name. The high concentration of potassium in plants means that heavy crop production rapidly depletes soils of potassium, and agricultural fertilizers consume 93% of the potassium chemical production of the modern world economy.
The functions of potassium and sodium in living organisms are quite different. Animals, in particular, employ sodium and potassium differentially to generate electrical potentials in animal cells, especially in nervous tissue. Potassium depletion in animals, including humans, results in various neurological dysfunctions. Characteristic concentrations of potassium in model organisms are: 30-300mM in E. coli, 300mM in budding yeast, 100mM in mammalian cell and 4mM in blood plasma.
Function in plants
Function in animals
Potassium is the major cation (positive ions) inside animal cells, while sodium is the major cation outside animal cells. The difference between the concentrations of these charged particles causes a difference in electric potential between the inside and outside of cells, known as the membrane potential. The balance between potassium and sodium is maintained by ion transporters in the cell membrane. All potassium ion channels are tetramers with several conserved secondary structural elements. A number of potassium channel structures have been solved including voltage gated, ligand gated, tandem-pore, and inwardly rectifying channels, from prokaryotes and eukaryotes. The cell membrane potential created by potassium and sodium ions allows the cell to generate an action potential—a "spike" of electrical discharge. The ability of cells to produce electrical discharge is critical for body functions such as neurotransmission, muscle contraction, and heart function.
The U.S. Institute of Medicine (IOM) sets Estimated Average Requirements (EARs) and Recommended Dietary Allowances (RDAs), or Adequate Intakes (AIs) for when there is not sufficient information to set EARs and RDAs. Collectively the EARs, RDAs, AIs and ULs are referred to as Dietary Reference Intakes. The current AI for potassium for women and men ages 14 and up is 4700 mg. AI for pregnancy equals 4700 mg/day. AI for lactation equals 5100 mg/day. For infants 0–6 months 400 mg, 6–12 months 700 mg, 1–13 years increasing from 3000 to 4500 mg/day. As for safety, the IOM also sets Tolerable upper intake levels (ULs) for vitamins and minerals, but for potassium the evidence was insufficient, so no UL established.
The European Food Safety Authority (EFSA) refers to the collective set of information as Dietary Reference Values, with Population Reference Intake (PRI) instead of RDA, and Average Requirement instead of EAR. AI and UL defined the same as in United States. For people ages 15 and older the AI is set at 3,500 mg/day. AIs for pregnancy is 3,500 mg/day, for lactation 4,000 mg/day. For children ages 1–14 years the AIs increase with age from 800 to 2,700 mg/day. These AIs are lower than the U.S. RDAs. The EFSA reviewed the same safety question and decided that there was insufficient data to establish a UL for potassium.
For U.S. food and dietary supplement labeling purposes the amount in a serving is expressed as a percent of Daily Value (%DV). For potassium labeling purposes 100% of the Daily Value was 3500 mg, but as of May 2016, it has been revised to 4700 mg. Compliance with the updated labeling regulations was required by 1 January 2020, for manufacturers with $10 million or more in annual food sales, and by 1 January 2021 for manufacturers with less than $10 million in annual food sales. During the first six months following the 1 January 2020 compliance date, the FDA plans to work cooperatively with manufacturers to meet the new Nutrition Facts label requirements and will not focus on enforcement actions regarding these requirements during that time. A table of the old and new adult Daily Values is provided at Reference Daily Intake.
Eating a variety of foods that contain potassium is the best way to get an adequate amount. Foods with high sources of potassium include kiwifruit, orange juice, potatoes, bananas, coconut, avocados, apricots, parsnips and turnips, although many other fruits, vegetables, legumes, and meats contain potassium.
Common foods very high in potassium:
- beans (white beans and others), dark leafy greens (spinach, Swiss chard, and others), baked potatoes, dried fruit (apricots, peaches, prunes, raisins; figs and dates), baked squash, yogurt, fish (salmon), avocado, and banana;
- nuts (pistachios, almonds, walnuts, etc.) and seeds (squash, pumpkin, sunflower)
The most concentrated foods (per 100 grams) are:
- dried herbs, sun dried tomatoes, dark chocolate, whey powder, paprika, yeast extract, rice bran, molasses, and dry roasted soybeans
High blood pressure/Hypertension
A severe shortage of potassium in body fluids may cause a potentially fatal condition known as hypokalemia. Hypokalemia typically results from loss of potassium through diarrhea, diuresis, or vomiting. Symptoms are related to alterations in membrane potential and cellular metabolism. Symptoms include muscle weakness and cramps, paralytic ileus, ECG abnormalities, intestinal paralysis, decreased reflex response and (in severe cases) respiratory paralysis, alkalosis and arrhythmia.
Adult women in the United States consume on average half the AI, for men two-thirds. For all adults, fewer than 5% exceed the AI. Similarly, in the European Union, insufficient potassium intake is widespread.
Side effects and toxicity
Gastrointestinal symptoms are the most common side effects of potassium supplements, including nausea, vomiting, abdominal discomfort, and diarrhea. Taking potassium with meals or taking a microencapsulated form of potassium may reduce gastrointestinal side effects.
Hyperkalemia is the most serious adverse reaction to potassium. Hyperkalemia occurs when potassium builds up faster than the kidneys can remove it. It is most common in individuals with renal failure. Symptoms of hyperkalemia may include tingling of the hands and feet, muscular weakness, and temporary paralysis. The most serious complication of hyperkalemia is the development of an abnormal heart rhythm (arrhythmia), which can lead to cardiac arrest.
Although hyperkalemia is rare in healthy individuals, oral doses greater than 18 grams taken at one time in individuals not accustomed to high intakes can lead to hyperkalemia. Supplements sold in the U.S. are supposed to contain no more than 99 mg of potassium per serving.
- Pohl, Hanna R.; Wheeler, John S.; Murray, H. Edward (2013). "Chapter 2. Sodium and Potassium in Health and Disease". In Astrid Sigel, Helmut Sigel and Roland K. O. Sigel (ed.). Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences. 13. Springer. pp. 29–47. doi:10.1007/978-94-007-7500-8_2. PMID 24470088.
- *Clausen, Michael Jakob Voldsgaard; Poulsen, Hanne (2013). "Chapter 3 Sodium/Potassium Homeostasis in the Cell". In Banci, Lucia (ed.). Metallomics and the Cell. Metal Ions in Life Sciences. 12. Springer. pp. 41–67. doi:10.1007/978-94-007-5561-1_3. ISBN 978-94-007-5560-4. PMID 23595670. electronic-book ISBN 978-94-007-5561-1 ISSN 1559-0836 electronic-ISSN 1868-0402
- Milo, Ron; Philips, Rob. "Cell Biology by the Numbers: What are the concentrations of different ions in cells?". book.bionumbers.org. Archived from the original on 20 April 2017. Retrieved 23 March 2017.
- Santoss JS, Asmar-Rovira GA, Han GW, Liu W, Syeda R, Cherezov V, Baker KA, Stevens RC, Montal M (Dec 2012). "Crystal structure of a voltage-gateds K+ channel pore module in a closed state in lipid membranes". J Biol Chem. 287 (51): 43063–70. doi:10.1074/jbc.M112.415091. PMC 3522301. PMID 23095758.
- Long SB, Campbell EB, Mackinnon R (August 2005). "Crystal structure of a mammalian voltage-dependent Shaker family K+ channel". Science. 309 (5736): 897–903. Bibcode:2005Sci...309..897L. doi:10.1126/science.1116269. PMID 16002581. S2CID 6072007.
- Jiang Y, Lee A, Chen J, et al. (May 2003). "X-ray structure of a voltage-dependent K+ channel". Nature. 423 (6935): 33–41. Bibcode:2003Natur.423...33J. doi:10.1038/nature01580. PMID 12721618. S2CID 4347957.
- Jiang Y, Lee A, Chen J, Cadene M, Chait BT, MacKinnon R (May 2002). "Crystal structure and mechanism of a calcium-gated potassium channel". Nature. 417 (6888): 515–22. Bibcode:2002Natur.417..515J. doi:10.1038/417515a. PMID 12037559. S2CID 205029269.
- Yuan P, Leonetti MD, Pico AR, Hsiung Y, MacKinnon R (July 2010). "Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution". Science. 329 (5988): 182–6. doi:10.1126/science.1190414. PMC 3022345. PMID 20508092.
- Wu Y, Yang Y, Ye S, Jiang Y (July 2010). "Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel". Nature. 466 (7304): 393–7. doi:10.1038/nature09252. PMC 2910425. PMID 20574420.
- Leonetti MD, Yuan P, Hsiung Y, Mackinnon R (Nov 2012). "Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel". Proc Natl Acad Sci U S A. 109 (47): 19274–9. Bibcode:2012PNAS..10919274L. doi:10.1073/pnas.1215078109. PMC 3511096. PMID 23129643.
- Kong C, Zeng W, Ye S, Chen L, Sauer DB, Lam Y, Derebe MG, Jiang Y (2012). "Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel". eLife. 1: e00184. doi:10.7554/eLife.00184. PMC 3510474. PMID 23240087.
- Brohawn SG, del Mármol J, MacKinnon R (January 2012). "Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel". Science. 335 (6067): 4s36–41. Bibcode:2012Sci...335..436B. doi:10.1126/science.1213808. PMC 3329120. PMID 22282805.
- Miller AN, Long SB (January 2012). "Crystal structure of the human two-pore domain potassium channel K2P1". Science. 335 (6067): 432–6. Bibcode:2012Sci...335..432M. doi:10.1126/science.1213274. PMID 22282804. S2CID 206537279.
- Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP (Mar 2015). "K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac". Science. 347 (6227): 1256–9. Bibcode:2015Sci...347.1256D. doi:10.1126/science.1261512. PMC 6034649. PMID 25766236.
- Clarke OB, Caputo AT, Hill AP, Vandenberg JI, Smith BJ, Gulbis JM (Jun 2010). "Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels". Cell. 141 (6): 1018–29. doi:10.1016/j.cell.2010.05.003. PMID 20564790. S2CID 14484301.
- Kuo A, Gulbis JM, Antcliff JF, Rahman T, Lowe ED, Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, Doyle DA (Jun 2003). "Crysstal structure of the potassium channel KirBac1.1 in the closed state". Science. 300 (5627): 1922–6. Bibcode:2003Sci...300.1922K. doi:10.1126/science.1085028. PMID 12738871. S2CID 2703162.
- Whorton MR, MacKinnon R (Sep 2011). "Crystal structures of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium". Cell. 147 (1): 199–208. doi:10.1016/j.cell.2011.07.046. PMC 3243363. PMID 21962516.
- Nishida M, MacKinnon R (Dec 2002). "Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution". Cell. 111 (7): 957–65. doi:10.1016/S0092-8674(02)01227-8. PMID 12507423. S2CID 15788511.
- Tao X, Avalos JL, Chen J, MacKinnon R (Dec 2009). "Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution". Science. 326 (5960): 1668–74. doi:10.1126/science.1180310. PMC 2819303. PMID 20019282.
- Mikko Hellgren; Lars Sandberg; Olle Edholm (2006). "A comparison between two prokaryotic potassium channels (KirBac1.1 and KcsA) in a molecular dynamics (MD) simulation study". Biophys. Chem. 120 (1): 1–9. doi:10.1016/j.bpc.2005.10.002. PMID 16253415.
- Potassium. IN: Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate Archived 2017-09-09 at the Wayback Machine. National Academy Press. 2005, PP.186-268.
- "Overview on Dietary Reference Values for the EU population as derived by the EFSA Panel on Dietetic Products, Nutrition and Allergies" (PDF). 2017. Archived (PDF) from the original on 2017-08-28.
- Tolerable Upper Intake Levels For Vitamins And Minerals (PDF), European Food Safety Authority, 2006, archived (PDF) from the original on 2016-03-16
- "Federal Register May 27, 2016 Food Labeling: Revision of the Nutrition and Supplement Facts Labels. FR page 33982" (PDF). Archived (PDF) from the original on August 8, 2016.
- "Daily Value Reference of the Dietary Supplement Label Database (DSLD)". Dietary Supplement Label Database (DSLD). Retrieved 16 May 2020.
- "FDA provides information about dual columns on Nutrition Facts label". U.S. Food and Drug Administration (FDA). 30 December 2019. Retrieved 16 May 2020. This article incorporates text from this source, which is in the public domain.
- "Changes to the Nutrition Facts Label". U.S. Food and Drug Administration (FDA). 27 May 2016. Retrieved 16 May 2020. This article incorporates text from this source, which is in the public domain.
- "Industry Resources on the Changes to the Nutrition Facts Label". U.S. Food and Drug Administration (FDA). 21 December 2018. Retrieved 16 May 2020. This article incorporates text from this source, which is in the public domain.
- "Top 10 Foods Highest in Potassium + One Page Printable". myfooddata. Archived from the original on 2014-09-11.
- Aburto NJ, Hanson S, Gutierrez H, Hooper L, Elliott P, Cappuccio FP (2013). "Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses". BMJ. 346: f1378. doi:10.1136/bmj.f1378. PMC 4816263. PMID 23558164.
- D'Elia L, Barba G, Cappuccio FP, Strazzullo P (2011). "Potassium intake, stroke, and cardiovascular disease a meta-analysis of prospective studies". J. Am. Coll. Cardiol. 57 (10): 1210–9. doi:10.1016/j.jacc.2010.09.070. PMID 21371638.
- Mumoli N, Cei M (2008). "Licorice-induced hypokalemia". Int. J. Cardiol. 124 (3): e42–4. doi:10.1016/j.ijcard.2006.11.190. PMID 17320224.
- What We Eat In America, NHANES 2013-2014 Archived 2017-02-24 at the Wayback Machine.
- "Archived copy" (PDF). Archived (PDF) from the original on 2011-07-13. Retrieved 2007-01-30.CS1 maint: archived copy as title (link) Energy and Nutrient Intake in the European Union
- "Potassium Health Professional Fact Sheet". NIH Office of Dietary Supplements. 3 April 2020.
- "Potassium". Drug Information Portal. U.S. National Library of Medicine.
- Brooks/Cole publishers – Sodium Potassium pump
- Oregon State University – Micronutrient Information Center
- Potassium at Lab Tests Online
- Potassium: analyte monograph - the Association for Clinical Biochemistry and Laboratory Medicine.