Poughkeepsie Bridge Route
The route specifically avoided the Port of New York, due to the lack of a rail crossing of North River (Hudson River). Instead it passed over the Poughkeepsie Bridge at Poughkeepsie, New York. Its Boston terminus at North Station, an advantage allowing for a direct transfer to Boston and Maine Railroad lines to the north.
The route used the following companies' lines:
- Baltimore and Ohio Railroad - Washington to Philadelphia
- Philadelphia and Reading Railroad - Philadelphia to Bethlehem, Pennsylvania (via the North Pennsylvania Railroad)
- Central Railroad of New Jersey - Bethlehem to Easton, Pennsylvania
- Lehigh and Hudson River Railway - Easton to Maybrook, New York
- Central New England and Western Railroad - Maybrook to Simsbury, Connecticut
- New York, New Haven and Hartford Railroad - Simsbury to Northampton, Massachusetts (via the New Haven and Northampton Company)
- Boston and Maine Railroad - Northampton to Boston (North Station) (via the former Central Massachusetts Railroad)
Parts of the route near the Poughkeepsie Bridge over the Hudson River have been converted to rail trails; the Hudson Valley Rail Trail to the west, the Poughkeepsie Bridge itself, and the Dutchess Rail Trail to the east.