Powassan virus

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Powassan virus
Virus classification
Group: Group IV ((+)ssRNA)
Order: Unassigned
Family: Flaviviridae
Genus: Flavivirus
Species: Powassan virus

Powassan virus is a flavivirus transmitted by ticks. The disease it causes is named after the town of Powassan, Ontario, where it was identified in a young boy who eventually died from it.


The Powassan Virus (POWV) is normally found in the warm climate across Eurasia where it is part of the TBE-complex.[1] The disease also exists in North America and can be transmitted with bites from the following species of Ixodes ticks: Ixodes cookei, Ixodes scapularis, Ixodes marxi and Ixodes spinipalpus. The ticks Dermacentor andersoni and Dermacentor variabilis are also vectors of the POWV.[2][3] There are a total of 6 known species of tick that act as vectors, with Ixodes cookei being the predominant species in Canada and the Northeastern United States and Ix. scapularis as a significant vector in Minnesota and Wisconsin.[3] There are rare cases in which Ix. cookei attaches to humans, and as a result the case-patients with POWV have been mostly confirmed as having the strain of POWV, the Deer tick virus (DTV). The Deer Tick Virus plays a vital role in maintaining the POWV and is vectored by Ix. scapularis.[1] Ix. scapularis is an important vector of the enzootic transmission cycle of the Deer Tick Virus.[1] Ix. scapularis is also a primary vector for the agent of Lyme disease because they are a generalist feeder and readily bite humans. The Powassan virus is transmitted by ticks among small mammals in eastern Canada and the United States, where it has been responsible for 49 deaths in the U.S. between 2000–2011.[verification needed][4] In North America, the Powassan Virus has been noted as the only tick-borne Flavivirus with human pathogenicity so far.[5]


The Powassan virus is rarely diagnosed as a cause of encephalitis; however, when it is, Powassan encephalitis is severe, and neurologic sequelae are common.[2] Powassan encephalitis has symptoms that are compatible with Acute disseminated encephalomyelitis, oftentimes making it difficult to diagnose.[2] Powassan virus encephalitis is a challenge to diagnose because there are only a few laboratories that offer testing, the most effective being serologic testing.[6] There are currently no medications or vaccines to treat or prevent the POWV. Victims of the Powassan virus generally show first symptoms after 1–3 weeks.[3] The initial symptoms for the POWV include: fever, headache, nausea, occasional confusion, and weakness.[7] With severe Powassan illnesses the victims should be hospitalized because the symptoms do worsen. If not treated symptoms could extend to meningoencephalitis, which may include: seizures, aphasia, cranial nerve palsies, paresis and altered mental status.[3][7] Currently the best ways to treat POWV illnesses include: medications to reduce brain swelling, respiratory support and intravenous fluids.[7] 10% of the POWV encephalitis cases are fatal and half of the survivors have permanent symptoms that affect their brain.[8]


The Powassan Virus is an RNA virus split into two separate lineages, Lineage I, labeled as the “prototype” lineage, and Lineage II, the Deer tick virus lineage.[1] Lineage II has the most genetic variation which indicates that it is most likely the ancestral lineage that split as a result of positive natural selection.[1] DTV is very closely related to Powassan virus and recent sequence analysis estimated that the two viruses diverged "approximately 200 years ago".[9] Even though lineage II has been predominant in POWV positive tick pools, both lineages have had confirmed cases of human disease in North America and Russia[3][7] The lineages share 84% nucleotide sequences and 94% amino acid sequence identity.[1] Cross-neutralization occurs among flaviviruses due to the conservation of the envelope protein, this is what contributes to the fact that the two lineages are “serologically indistinguishable”.[2] As a result, the lineages are part of the same viral species. The Powassan virus is also found in the Russian Far East (Primorsky Krai) and appears to have been introduced there 70 years ago.[10]


In North America, the lineages of the POWV are maintained in 3 main enzootic cycles.[1] These cycles involve the ticks Ix. cookei, Ix. marxi, and Ix. scapularis, and small to medium-sized woodland mammals.[1] Woodchucks and Ix. cookei, squirrels and Ix. marxi, and white-footed mice and Ix. scapularis are the enzootic cycles in which the virus is maintained.[7] The POWV is transmitted from the bite of an infected tick and in humans the Ix. scapularis tick is notorious for being the attacker.[11] The fastest transmission time of DTV from a nymph Ix. scapularis to a mouse was no more than 15 minutes.[12] Based on the time interval for the other tick-borne diseases Lyme disease and anaplasmosis, the time interval for transmission of POWV is expected to be less than 12 hours.[8] Once the POWV reaches humans it cannot be transmitted to a feeding tick, therefore humans are considered “dead-end” hosts.[7]


When it comes to the Powassan virus and any other tick-borne disease, prevention is the most important thing to do when it comes to protecting your health as well as your pets. In the prevention of humans being bitten by a tick, it would be best to avoid areas that are densely wooded and/or covered with tall grass as that type of habitat is ideal for hosting ticks. In addition, wearing light colored clothing that covers all parts of your skin (long sleeves, tall socks) would also help locate ticks on your body as well as keep them from being able to attach directly to your skin.[13] Self tick checks should be done every-time after you are done playing outside. It can also be beneficial to have a friend or family member check over your body and vice versa. In the prevention of animals being bitten by a tick, note that signs and symptoms may not arise for 7 to 21 days so be sure to monitor you pet very closely; especially if they have been outdoors in areas where ticks are more than likely to dwell. In addition, after spending time with your pet outdoors make sure to do a full body check to search for ticks that may have found themselves hitching a ride. It may also be a good idea to use a tick/bug repellent ointment that you can receive from your primary veterinarian.[14]


  1. ^ a b c d e f g h Ebel, Gregory D.; Doug E. Brackney; Ivy K. Brown; Robert A Nofchissey; Kelly A. Fitzpatrick (5 July 2010). "Virology". Elsevier. 402 (2): 366–371. doi:10.1016/j.virol.2010.03.035. Retrieved 27 October 2013. 
  2. ^ a b c d Hicar, Mark; Edwards, Kathryn; Bloch, Karen (2011). "Powassan Virus Infection Presenting as Acute Disseminated Encephalomyelitis In Tennessee". The pediatric infectious disease journal. 30 (1): 86–88. doi:10.1097/INF.0b013e3181f2f492. PMID 20736878. 
  3. ^ a b c d e >Birge, Justin; Steven Sonnesyn (October 2012). "Powassan Virus Encephalitis". Emerging Infectious Diseases. 18 (10): 1669–1671. doi:10.3201/eid1810.120621. PMC 3471639Freely accessible. PMID 23017222. 
  4. ^ Birge, Justin; Sonnesyn, Steven (2012). "Powassan Virus Encephalitis, Minnesota, USA". Emerging Infectious Diseases. 18 (10): 1669–71. doi:10.3201/eid1810.120621. PMC 3471639Freely accessible. PMID 23017222. 
  5. ^ Dobler, Gerhard (2010). "Zoonotic tick-borne flaviviruses". Veterinary Microbiology. 140 (3–4): 221–8. doi:10.1016/j.vetmic.2009.08.024. PMID 19765917. 
  6. ^ Neitzel, David F; Ruth Lynfield; Kirk Smith (April 2013). "Powassan Virus Encephalitis". Emerging Infectious Diseases. 19 (4): 686. doi:10.3201/eid1904.121651. 
  7. ^ a b c d e f Centers for Disease Control and Prevention. (2010). Powassan. Retrieved from http://www.cdc.gov/powassan/
  8. ^ a b "Minnesota Department of Health". Powassan. MDH. Retrieved 27 October 2013. 
  9. ^ Pesko, KN.; Torres-Perez, F.; Hjelle, BL.; Ebel, GD. (Nov 2010). "Molecular epidemiology of Powassan virus in North America". J Gen Virol. 91 (Pt 11): 2698–705. doi:10.1099/vir.0.024232-0. PMC 3052558Freely accessible. PMID 20631087. 
  10. ^ Subbotina EL, Loktev VB (2012). "Molecular evolution of the tick-borne encephalitis and Powassan viruses". Mol. Biol. 46 (1): 75–84. doi:10.1134/S0026893311060148. PMID 22642104. 
  11. ^ Ebel, Gregory D. (11 August 2009). "Update on Powassan Virus: Emergence of a North American Tick-Borne Flavivirus". Annual Review of Entomology. 55 (1): 95–100. doi:10.1146/annurev-ento-112408-085446. PMID 19961325. 
  13. ^ Johnson, D. K., Staples, J. E., Sotir, M. J., Warshauer, D. M., & Davis, J. P. (2010). Tickborne Powassan virus infections among Wisconsin residents. WMJ, 109(2), 91-97. Retrieved from https://www.researchgate.net/profile/David_Warshauer2/publication/44573978_Tickborne_Powassan_virus_infections_among_Wisconsin_residents/links/02e7e52defcd81dae9000000.pdf.
  14. ^ Center for Disease Control. (2015). Powassan virus: Preventing Ticks on Your Pets. Retrieved from https://www.cdc.gov/ticks/avoid/on_pets.html