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Powell Creek or Powells Creek may refer to:
- Powells Creek (Sydney), a tributary of the Parramatta River in Sydney, New South Wales, Australia
- Powell Creek (New York), a tributary of Groves Creek in Seneca County
- Powell Creek (Pennsylvania), a tributary of the Susquehanna River in Dauphin County, Pennsylvania, United States
- Powell Creek, West Virginia, an unincorporated community in Boone County, West Virginia, United States
- Powell's Creek (Prince George County, Virginia), a tributary of the James River in Prince George County, Virginia, United States
- Powells Creek (Prince William County, Virginia), a river near Montclair, Virginia, United States
- Powell's Creek Church, in Hancock County, Georgia, United States
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