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A pox is a type of disease, often caused by an animal virus, characterised by pockmarks. The term may be used (in an archaic sense) to refer to disease.

Pox, as a disease, may refer to:

  • Poxviruses
    • Cowpox
    • Smallpox, an infectious disease unique to humans, caused by either of two virus variants, Variola major and Variola minor
    • Monkeypox, an exotic infectious disease caused by the monkeypox virus
    • Black pox, a symptom of smallpox caused by bleeding under the skin, which makes the skin look charred or black and usually indicates that a patient with smallpox is going to die
    • Canarypox, an Avipoxvirus and etiologic agent of canarypox, a disease of wild and captive birds that can enter humans but is unable to survive or multiply in human cells
  • Potyviridae, a family of plant viruses
    • Plum pox, the most devastating viral disease of stone fruit from the genus Prunus
  • Herpes viruses
    • Chickenpox, a highly contagious illness caused by primary infection with varicella zoster virus (VZV)
  • Syphilis, a sexually transmitted disease caused by the spirochetal bacteria Treponema pallidum subspecies pallidum
  • Rickettsialpox, a rickettsial disease spread by mites

In computing, it may refer to:

  • Pox: Save the People, a 2010 board game and mobile game
  • P-O-X, a 2001 handheld electronic game
  • PoxNora, a 2006 multiplayer online game that combines a collectible card game with a turn-based strategy game in a fantasy setting
  • Plain Old XML, basic XML, a computer data representation format
  • Orthopox 13, a character in the video game series Destroy All Humans!

In other uses, pox or POX may refer to:

  • Pox (drink), a ceremonial drink common among the Maya, especially those in Chamula
  • POx, premature oxidation of wine
  • Partial oxidation, a chemical reaction
  • The P.O.X., a German band
  • Pox, small rounded pegs of candy that are attached to a strip of paper
  • President's Overseas XV, a 1971 rugby union squad, chosen to celebrate the centenary of the English Rugby Football Union, the oldest national rugby organisation in existence