A prairie oyster (sometimes also prairie cocktail) is a traditional beverage consisting of a raw egg (often yolk alone), Worcestershire sauce, vinegar and/or hot sauce, table salt and ground black pepper. Tomato juice is sometimes added, reminiscent of a Bloody Mary. The egg is broken into a glass so as not to break the yolk. The mixture is quickly swallowed. The unbroken yoke causes the drink to bear a texture similar to that of an oyster. The concoction has been referred to as a traditional cure for hangovers, and has appeared in media for decades.
In the 1990 film Back to the Future Part III, Marty pours the (egg-free) "wake-up juice" into Doc's stomach to wake him up after he instantly passes out from a shot of whiskey in the Old West.
In the Japanese animeCowboy Bebop, the main character Spike Spiegel is seen making a prairie oyster to help with a hangover in the episode Heavy Metal Queen. The bartender, however, adds one or two shots of what appears to be gin; the bottle reads 'BOOFEATER', most likely referencing Beefeater Gin.
In the video game Catherine, the drink is referenced in one of the many cocktail trivia segments that can occur in the bar.
In the American TV show Shameless, the character Mickey is seen preparing one in "The Alibi". (Season 4, Episode 1)
In Thunderball, the 1961 novel by Ian Fleming, prior to spending a fortnight at Shrublands ("Gateway to Health"), James Bond (Sean Connery) states that "there wasn't a week went by but that on at least one day I couldn't eat anything for breakfast but a couple of aspirins and a prairie oyster".
In the Netflix series Russian Doll, the main character Nadia is seen making a prairie oyster to help with a hangover in the episode "The Great Escape" (Season 1, Episode 2).