Prashanthini first began her playback career with Harris Jayaraj for the movie 12B. However, after this song, she took a long break and came back in the G. V. Prakash Kumar composed film Veyyil. She became instantly famous after singing the song "Mundhinam Parthene" for the movie Varanam Aayiram composed by Harris Jayaraj. Now she is singing for many composers and hopes for a long innings in playback singing without falling under her father's shadows.Her Ayyayo... (Aadukalam), Lolita... (Engeyum Kaadhal), Enge En Idhayam... (Kandaen) and Ennamo Yedho... (Ko), feature among the top 20 popular songs on FM radio. All the four numbers are melodies that have caught the imagination of the youth. In the world of film music, people are trying to track down this elusive singer with a sweet melodious voice. 
Prashanthini was born in September 28, 1983.She finished Bachelor of computer application.She got married Premnath in 2008 and she has a son named Rithvik. Coincidentally, the movie 12B in which she sang her debut song was released on her birthday.