T-lymphoblastic leukemia/lymphoma (WHO 2008),:219 previously labeled precursor T-lymphoblastic leukemia/lymphoma (WHO 2001):219 and also known as precursor T-cell lymphoblastic lymphoma and precursor T acute lymphoblastic leukemia/lymphoma is a form of lymphoid leukemia and lymphoma in which too many T-cell lymphoblasts (immature white blood cells) are found in the blood, bone marrow, and tissues, particularly mediastinal lymph nodes.:635 Labeling as leukemia or lymphoma depends on which feature is more pronounced in a given situation, but has no biological or treatment implication.:635
It is uncommon in adults, but represents 15% of childhood acute lymphoblastic leukemia and 90% of lymphoblastic lymphoma.:635
The 2008 terminology dropped "precursor" to avoid linguistic redundancy because the lymphoblast is an immature precursor cell by definition.:219
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- ^ Kim MA, Lee GW, Maeng KY (August 2005). "An unusual presenting feature of precursor T-cell acute lymphoblastic leukemia/lymphoma". Ann. Hematol. 84 (8): 553–4. doi:10.1007/s00277-005-1042-4. PMID 15843931.
- ^ Lyman MD, Neuhauser TS (April 2002). "Precursor T-cell acute lymphoblastic leukemia/lymphoma involving the uterine cervix, myometrium, endometrium, and appendix". Ann Diagn Pathol 6 (2): 125–8. doi:10.1053/adpa.2002.32381. PMID 12004362.
- ^ Han X, Bueso-Ramos CE (April 2007). "Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias". Am. J. Clin. Pathol. 127 (4): 528–44. doi:10.1309/2QE3A6EKQ8UYDYRC. PMID 17369128.
This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".