Pregnancy-associated plasma protein A

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PAPPA
Identifiers
AliasesPAPPA, ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1, pappalysin 1
External IDsOMIM: 176385 MGI: 97479 HomoloGene: 31097 GeneCards: PAPPA
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for PAPPA
Genomic location for PAPPA
Band9q33.1Start116,153,791 bp[1]
End116,402,321 bp[1]
RNA expression pattern
PBB GE PAPPA 201982 s at fs.png

PBB GE PAPPA 201981 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002581

NM_021362

RefSeq (protein)

NP_002572

NP_067337

Location (UCSC)Chr 9: 116.15 – 116.4 MbChr 4: 65.12 – 65.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pappalysin-1, also known as pregnancy-associated plasma protein A, is a protein encoded by the PAPPA gene in humans. PAPPA is a secreted protease whose main substrate is insulin-like growth factor binding proteins. Pappalysin-1 is also used in screening tests for Down syndrome.[5][6]

Function[edit]

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). PAPPA's proteolytic function is activated upon collagen binding. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses (fetuses with an abnormal number of chromosomes).[6] For example, low PAPPA may be commonly seen in prenatal screening for Down syndrome.[5] Low levels may alternatively predict issues with the placenta, resulting in adverse complications such as intrauterine growth restriction, preeclampsia, placental abruption, premature birth, or fetal death.

Interactions[edit]

Pregnancy-associated plasma protein A has been shown to interact with major basic protein.[7][8][9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182752 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028370 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Breathnach FM, Malone FD (2007). "Screening for aneuploidy in first and second trimesters: is there an optimal paradigm?". Curr. Opin. Obstet. Gynecol. 19 (2): 176–82. doi:10.1097/GCO.0b013e3280895e00. PMID 17353686. S2CID 25949255.
  6. ^ a b "Entrez Gene: PAPPA pregnancy-associated plasma protein A, pappalysin 1".
  7. ^ Overgaard MT, Haaning J, Boldt HB, Olsen IM, Laursen LS, Christiansen M, Gleich GJ, Sottrup-Jensen L, Conover CA, Oxvig C (October 2000). "Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor". J. Biol. Chem. 275 (40): 31128–33. doi:10.1074/jbc.M001384200. PMID 10913121.
  8. ^ Overgaard MT, Sorensen ES, Stachowiak D, Boldt HB, Kristensen L, Sottrup-Jensen L, Oxvig C (January 2003). "Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment". J. Biol. Chem. 278 (4): 2106–17. doi:10.1074/jbc.M208777200. PMID 12421832.
  9. ^ Oxvig C, Sand O, Kristensen T, Gleich GJ, Sottrup-Jensen L (June 1993). "Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein". J. Biol. Chem. 268 (17): 12243–6. PMID 7685339.

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M43.004